Monthly Archives: April 2017

, 2010), such as might arise if naive animals experienced greater fluctuations in arousal during the session. Signal correlation (rsignal) was computed as the Pearson correlation coefficient (ranging between −1 and 1) between the tuning curves from two simultaneously recorded … Continue reading →

This was the case in every trial for all animals (Figure 2A). Which aspects of the motor and sensory activity determine the timing of the jump? We found that the time at which the cocontraction ended (triggering) was highly correlated with … Continue reading →

, 1977). Finally, in humans, some sleep disorders (e.g., sleep walking) suggest the existence of “dissociated states” (Mahowald and Schenck, 2005), where some brain regions are “asleep” when others are simultaneously “awake. Given the recent evidence supporting local regulation of … Continue reading →

These data were reported for male and female patients separately and for different age categories. Moreover, these data were compared with a normative group. The second article focuses on the adherence to different health and fitness guidelines and which factors … Continue reading →

, 2005, Miller and Katz, 2013, Usher and McClelland, 2001 and Wong and Wang, 2006) along with a variety of extensions that overcome sensitivity to mistuning (Cain VEGFR inhibitor et al., 2013, Goldman et al., 2003 and Koulakov et al., 2002). These theories would support integration within … Continue reading →

1% ± 3.0%, n = 6 and 66.0% ± 3.7%, n = 7, respectively) (Figure 4B). The observations support the notion that protons and Gu+ have a single common pathway and that, in the open state of the channel, R3 creates a barrier in a … Continue reading →

There were a number of other occasions of exuberant joy as we unveiled new secrets, especially our realization that there is a critical period of development early in the life of cats and monkeys. D.H.: I’m always impressed Screening Library … Continue reading →

, 2005, Andretic et al., 2008 and Crocker and Sehgal, 2010). Perhaps the greatest potential of Drosophila for understanding the regulation and function of sleep, however, resides Tyrosine Kinase Inhibitor Library in vitro in employing forward genetic screens to identify genes that regulate … Continue reading →

, 1994) However, synaptotagmins do not function alone but require the presence of complexins, BMS-354825 supplier which are small soluble proteins that bind to SNARE complexes (McMahon et al., 1995). Complexins perform several functions in presynaptic exocytosis: priming of synaptic vesicles … Continue reading →

In adult mice of all ages, voluntary Selleckchem Tyrosine Kinase Inhibitor Library running stimulates cell proliferation and neurogenesis in the hippocampus (van Praag et al., 1999 and van Praag et al., 2005). Neurogenesis and neural stem cell frequency in the forebrain subventricular zone are … Continue reading →