[9,14] Individuals with lower concentrations showed a significantly Palbociclib manufacturer lower mean number of decayed surfaces compared with the individuals with higher concentrations of mutans streptococci in their saliva.[21] Results of a recent study conducted in Japan showed that high levels of mutans streptococci (MS) correlated with the onset of primary and secondary caries, with odds ratios of 2.34 and 2.22, respectively.[22] According to some other study reports, levels of MS were not associated with high caries experience which is contradictory to the results of the present study.[23,24] Considering the relation between DMFT and gender, the mean of DMFT was higher among females than in the males in the present study. When dental caries rates were reported by gender in the dental literature, females were found to exhibit typically higher prevalence rates than males.
This finding is generally true for diverse cultures and for a wide range of chronological periods.[25,26,27] A high caries rate in females can be attributed to frequent snacking and hormonal imbalance during events such as puberty, menstruation, and pregnancy.[27] A cross-sectional study design was used in the present study to determine the correlation between S. mutans and dental caries experience like several other studies. But a single saliva sample would record the microbial counts at one particular point of time and its well understood that dental caries develops over a considerable period of time, during which bacterial counts would fluctuate in response to the changing oral environment.
[28] CONCLUSION Longitudinal studies, where microbial samples are taken at regular intervals would help to study the variation in counts of microorganisms. However, the results of this study will add to the existing data on the gender differences in caries, which can be used for planning preventive programs in adults, to reduce the reservoir of S. mutans and hence prevent its transmission to the infants and adults. Footnotes Source of Support: Nil. Conflict of Interest: None declared
The word chemoprevention includes prevention of initiation, promotion, and progression of carcinogenesis to cancer. Michael B. Sporn coined the term chemoprevention in a 1976 article in Federation Proceedings, when writing about the work his group was doing with vitamin A analogs.[1] This definition was in contrast with the use of the term ��chemotherapy�� by Professor Paul Ehrlich in the early 20th century Anacetrapib to describe a synthetic agent employed to treat disease.[2] Cancers of the oral cavity represent the sixth most prevalent cancer worldwide.[3] Oral cancer is a major health problem in some parts of the world, especially in developing countries.
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