Analyses were performed using Prism for Windows, version 4 03 (Gr

Analyses were performed using Prism for Windows, version 4.03 (GraphPad Software, Inc., La Jolla, CA). The two-sided level of significance was set at 0.05. Results Baseline characteristics A total of 42 patients were screened, 34 underwent randomization, and 25 completed 8 weeks of treatment (Supplementary Figure 1, all supplementary material can be found online with this article,

Supplementary Inhibitors,research,lifescience,medical Table 1 provides a summary of the demographic and patient characteristics. At baseline, the EGCG and placebo groups did not differ significantly on any of the demographic variables or psychiatric symptom rating scales. Concurrent psychiatric medications at baseline are Torkinib in vitro reported in Supplementary Table 2. Efficacy The CGI score improved significantly from baseline to week 10 (i.e. 8 weeks of EGCG treatment for the EGCG group) in both the EGCG and placebo groups (F = 15.46, p = 0.0006). There was a trend for a treatment effect (F = 3.90, p =

0.059); however, the interaction between treatment Inhibitors,research,lifescience,medical group and time did not reach statistical significance (Figure 1). The PANSS, HAM-A, and HAM-D scores also improved significantly from baseline to week 10 in both treatment Inhibitors,research,lifescience,medical groups (PANSS: F = 15.46, p < 0.0001; HAM-A: F = 6.50, p = 0.0032; HAM-D: F = 9.71, p = 0.0003), but the group and group × time interaction effects were not significant (Figure 1). Further, the EGCG and placebo groups did not significantly Inhibitors,research,lifescience,medical differ in the change from baseline to week 10 on any of the psychiatric measures, including the subscales for the PANSS (Table 1). Figure 1. Epigallocatechin-3-gallate (EGCG) versus placebo: clinical assessment results. Mean (± Inhibitors,research,lifescience,medical SEM) scores by group for all research participants completing 10 weeks of the study are shown. (a) Clinical Global Impressions (CGI). The CGI was administered ... Table 1. Change in psychiatric rating scales from baseline to week 10 according to treatment group. Safety and tolerability Three AEs

were reported during the trial. One patient in the EGCG group experienced an exacerbation of bipolar depression and was discontinued from study medications at week 10, one patient in the placebo group reported tachycardia and was discontinued from study medications at week 10, and one patient in the mafosfamide placebo group developed an abdominal rash and was discontinued from the study prior to week 6 (Supplementary Figure 1). The EPS measures (SAS and AIMS) remained overall unchanged for both groups (data not shown); however, both measures showed levels already very low at baseline (Supplementary Table 1). Biomarker assays Cytokine levels were measured to determine whether treatment with EGCG was associated with alterations in the production of TNF-α, IFN-γ, IL-10, and IL-9.

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