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and information source focused on the defensins family of antimicrobial peptides. Nucleic Acids Res 2007, 35:D265–268.PubMedCrossRef 28. Wang CK, Kaas Q, Chiche L, Craik DJ: CyBase: a database of cyclic protein sequences and structures, with applications in protein selleck compound discovery and engineering. Nucleic Acids Res 2008, 36:D206–210.PubMedCrossRef 29. Whitmore L, Wallace BA: The Peptaibol Database: a database for sequences and structures of naturally occurring peptaibols. Nucleic Acids Res 2004, 32:D593–594.PubMedCrossRef 30. Wu CH, Apweiler R, Bairoch A, Natale DA, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, et al.: The Universal Protein Resource (UniProt): an expanding universe of protein information. Nucleic Acids Res 2006, 34:D187–191.PubMedCrossRef SAHA HDAC 31. Hunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, et al.: InterPro: the integrative protein signature database. Nucleic Acids Res 2009, 37:D211–215.PubMedCrossRef

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AA, Aravind L, Madden TL, Shavirin S, Spouge JL, Wolf YI, Koonin EV, Altschul SF: Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements. Nucleic Acids Res 2001, 29:2994–3005.PubMedCrossRef 35. Goodridge LD: Design of phage cocktails for therapy from a host range point of view. heptaminol In Enzybiotics: antibiotic enzymes as drugs and therapeutics. 1st edition. Edited by: Villa TG, Veiga-crespo P. New Jersey: John Wiley &Sons, Inc.,Publication; 2010:199–218. 36. Donovan DM, Dong S, Garrett W, Rousseau GM, Moineau S, Pritchard DG: Peptidoglycan hydrolase fusions maintain their parental specificities. Appl Environ Microbiol 2006, 72:2988–2996.PubMedCrossRef 37. Sayle RA, Milner-White EJ: RASMOL: biomolecular graphics for all. Trends Biochem Sci 1995, 20:374.PubMedCrossRef Authors’ contributions HW developed the web interface, designed the rational database scheme, and qualified the data. HL and JH primarily contributed to inputting the data into the current database, as well as in writing the manuscript. GL and QH conceived of the initial idea of the database, provided direction for its development, and revised the subsequent drafts of this manuscript. All authors read and approved the final manuscript.”
“Background Antibiotic resistance is a serious threat to human and animal health and new ways to combat it are urgently needed.

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