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“Background Microorganisms, because of their phenomenal biodiversity, are a rich natural resource of many biologically active compounds such as proteins, CDK inhibition polyunsaturated fatty acids, pigments and polysaccharides [1, 2]. Metabolites produced by microorganisms often display high biological activities and their potential health benefits make them valuable ingredients in nutraceuticals, cosmetics
and the food industry [3, 4]. Moreover, investigations related to the search for new bioactive compounds from industrially important microbial strains are of continued importance because of the high potential economic value of these metabolites [5, 6]. Demand for carotenoid Axenfeld syndrome (CT) pigments has been growing annually at a rate of 3.1% and is a market predicted to reach at least US$ 1.17 billion in value by 2012 as consumers continue to look for natural alternatives. Among them, canthaxanthin (CX) is used extensively in the food, fishery, cosmetic, and pharmaceutical industries [7, 8]. D. natronolimnaea is one of the most important sources for the microbial production of CX from a commercial and industrial point of view [9, 10]. To meet the growing demand of CX, a cost effective scaling-up of the industrial process is imperative . In conventional methodology, nutritional factors and others necessary for growth of the microorganism are optimized by changing one at a time while keeping all others constant. .
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