The discrepancy between the NHS and the JIKEI/KYOTO HEART Studies may partially be explained by the difference MDV3100 in the coitant medications and the study design. We applied the prospecti randomiz open-label blinded endpoints method to assess oues. The prospecti randomiz open-label blinded endpoints design is relatively vulnerable to reporting bi because allocated drugs are open to both patients and physicians. In this rega softer end points should be adjudicated with a special care. In the present stu an independent clinical research nurse coordinator group managed nist Losartan Study showed that ARB was particularly effective to follow up patient records and to collect the data in 0 of against diabetic nephropathy in Japanese patientspared with other ethnicities.
5 Taken togeth ARB may have a greater potential to reduce the risk of HFpared with C espe-cially in Japanese hypertensive patients with glucose intolerance. patien and all of the reported adverse events were strictly adjudicated by an independent end point evaluationmittee under a blinded manner as to the drug assignment. In fa among provisional repor only were adjudi-Downloaded Lapatinib clinical trial from hyper.ahajournals/ by guest on March 7, Muramatsu ARB vs CCB in Diabetic Hypertensive Patients cated as the primary end point by themittee. Therefo we believe that the bias would be highly unlikely to account for the differences. Rath prospecti randomiz open-label blinded endpoints design is close to daily clinical practice and less stressful to patients. 8 Our patients were relatively well controlled in both blood pressure and glycemic status.
A recent international cohort study reconfirmed that the incidence of CVD was significantly lower in Japanpared raltegravir structure with other countries. 9 These underlying conditions might result Marbofloxacin solubility in quite lower incidence of primary oues than we anticipated. In additi the sample size was less than the initially planned number of sample and that the present study was underpow-ered to determine our initial hypothesis that ARB might be more effective in preventing major CV events than CCB. Howev postcensored analysis indicated acceptable statistical powe the risk of primary oue in each group was almost eve and our results were consistent with previous clinical evidence. 4 Perspectives The NHS is the first randomiz controlled trialparing the clinical efficacies of ARB and CCB in Japanese hypertensive patients with glucose intolerance.
posite major CV events were similarly observed between ARB-based and CCB-based antihypertensive treatment. Howev HF was more significantly reduced by ARB regimen. The NHS results echo those of the IDNT CV event trial and confirm the efficacy of ARB in this patient population in diabetic hypertensive patients in East Asia. . NAVIGATOR Study rule against perpetuities Group. Effect of valsartan on the incidence of diabetes and cardiovascular events.Engl J Med . Heart Oues Prevention Evaluation Study Investigators. Effects of ramipril on cardiovascular and microvascular oues in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 9. 0. Brenner Cooper de Zeeuw D, Keane Mitch Parving Remuzzi G, Snapinn Zhang Z, Shahinfar S; RENAAL Study Investigators. Effects of losartan on renal and cardiovascular oues in patients with type diabetes .
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