The infected group had lower hematocrit values than those in the control group in the last weeks of the experiment, but all the values observed for both groups were within the normal range according to other authors (Lucas and Jamroz, 1961 and Campbell and Dein, 1984). Some authors mention anemia in poultry Screening Library cell line infected by P. juxtanucleare
with high parasitemia, but this did not occur in this study, probably due to the low parasite load in the infected birds. With respect to the activity of the hepatic ALT and AST enzymes, reports in the literature mention that factors related to climate, type of food and management can influence the results of these analyses (Borsa et al., 2006). In the first week of the experiment, the control and infected groups showed higher activity of AST and ALT than in the other weeks. A possible explanation is that the fowls, still adapting Metabolism inhibitor to being handled to collect blood samples, could have been stressed, but as the experiment proceeded the birds were better acclimated, reducing the stress, and the parameters were only affected by the infection. In the second week, both enzymes presented a profile similar to the baseline value, except
for the infected group in relation to the ALT activity, demonstrating that this enzyme is altered by infection by P. juxtanucleare, since its respective control did not differ significantly from the baseline value. The peak parasite load occurred at the start of the second week after inoculation and the highest ALT activity in the infected group occurred at the end of the first week and start of the second week. There was a positive
correlation between the peak parasitemia and highest ALT activity. ALT is predominantly found in the hepatocytes, located in the cytoplasm. Aggression to the found hepatocytes triggers the release of ALT. The activity of this enzyme in small animals such as chickens is widely used to determine hepatics pathologies ( Kramer, 1989). Studies revealed that ducks inoculated with the hepatitis virus showed higher activity of ALT ( Ahmed et al., 1961). The increase in the serum activity of these enzymes attributed to hepatic dysfunction can be due to the rupture of hepatocytes, resulting in necrosis or alterations of the permeability of the cell membrane or a process of cholestasis ( Kaneco, 1989). The activity of AST did not vary significantly in the infected group in relation to the control group during the experiment. Some authors have mentioned cases of chronic hepatic damage that produced subtle ruptures in the hepatics cells, but without altering the normal serum activity of AST (Fudge, 2000). This enzyme is considered a non-specific market because it is found in various tissues, but it is also considered a highly sensitive indicator of tissue lesion, more closely related to recent tissue injury and reduced organ function (Lumeij and Westerhof, 1987).
Related posts:
- 31 Mpa (Graphs (Graphs22 and and3),3), Group II = 7 37 Mpa (Gra
- Eight-week-old female BALB/c mice (5 per group) were vaccinated w
- P2X Receptor patients in the OPD group did not have a CR in the delayed period
- nimals in the TGF B blockade group received one intraperitoneal
- Extending the alkyl group from ethyl to pentyl as in compound t r