Upon review of subjects with psychiatric disorders, approximately 70% had evidence of prior healthcare visits for similar diagnoses within the Kaiser Permanente database; overall and for specific diagnoses, the proportion with evidence of see more prior visits was similar for LAIV and controls. A temporal analysis of these conditions showed no evidence of clustering of events within the 42 days postvaccination. Asthma and wheezing events were evaluated in detail. There were a total of 17 statistically significant rate comparisons in the asthma and wheezing PSDI analysis;
all events occurred at lower rates in LAIV recipients relative to controls. For asthma and wheezing events captured under the PSDI category of acute respiratory tract events, 7 rate comparisons of asthma/RAD events and 3 rate comparisons of wheezing/SOB events were significantly decreased in LAIV recipients Panobinostat research buy relative to controls. For asthma and
wheezing events analyzed by individual MAEs, asthma events occurred at a lower rate in LAIV recipients relative to controls in 7 rate comparisons in the clinic setting and 1 rate comparison in the ED setting. Exercise-induced asthma events occurred at lower rates in LAIV recipients relative to controls in 2 rate comparisons in the clinic setting, and wheezing events occurred at lower rates in LAIV recipients relative to controls in 3 rate comparisons in the clinic setting. All but 1 of these rate comparisons
occurred in comparison with those vaccinated with TIV. There were no asthma/wheezing events that occurred at a higher rate in LAIV recipients relative to controls in any of the above analyses (see Supplemental Digital Content 2, which shows hazard ratios of asthma and wheezing events after vaccination with LAIV versus comparators). No anaphylaxis events occurred within the 3-day risk period postvaccination in either LAIV recipients or any control group. Within 3 days of LAIV vaccination there were 9 cases of urticaria (8 in the clinic setting and 1 in the ED setting). PAK6 The rate of urticaria within 3 days of vaccination was not significantly increased or decreased in LAIV recipients relative to control groups in any comparison. After the post hoc adjustment for multiple comparisons, 48 of the 372 incidence rate comparisons remained statistically significant (Table 4 and Table 5). In children 5–8 years of age, events occurring at an increased rate after vaccination with LAIV were psychiatric conditions, vision disorders, and well care visits; all were relative to unvaccinated controls. Events occurring at a lower rate after vaccination with LAIV included any acute respiratory tract event, any asthma and wheezing event, asthma and asthma/RAD; all were relative to TIV-vaccinated controls.
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- 5 The subjects included in the study were aged 15 to 54 years and