Monthly Archives: April 2017

Significance was set at p 

SLd is thus the relative drop in Rd at location d due to the activation of single (or multiple) steady conductance changes at arbitrary dendritic locations (see Figures S8 and S9 and related text available online for generalization to the … Continue reading →

While the term “impact peak” can still refer to a transient that exhibits a local maximum, a local maximum is not a necessary condition for existence of an impact transient. The current study demonstrates that novice BF runners are successful … Continue reading →

Since advancing age gradually increases stressor load as long as underlying causes are present, strategies targeting cellular stressor pathways should aim at processes that are critical to drive vicious circles of increasing cellular stress and misfolding protein acumulation. Such critically … Continue reading →

Spike sorting was performed by a semiautomatic clustering procedure (see Supplemental Experimental Procedures and Figure S5), yielding a total of 140 active pyramidal neurons during sleep (n = 4 animals), 573 in the maze (n = 3 animals), 569 during wheel running (n = 3 … Continue reading →

In these instances, it is now technically possible to conduct ChIP and DNA methylation studies after selecting fluorescently tagged cell types with flow cytometry (Guo et al., 2011 and Jiang et al., 2008). In addition to basic research, there is the potential for the … Continue reading →

, 2011), leading to the features of the disease (Schon and Area-Gomez, 2010). One other neurodegenerative disease that may be associated with MAM dysfunction is CMT, which can be caused by mutations both in MFN2 (Chen and Chan, 2009) and … Continue reading →

, 1997]) and impaired corticosteroid receptor signaling (Holsboer, 2000), more recent hypotheses include the involvement of neurotrophins (Samuels and Hen, 2011), fibroblast growth factors (both ligands and receptors) (Turner et al., 2012), GABAergic deficits (Luscher et al., 2011), and epigenetic changes, specifically … Continue reading →

In plots of power spectral density (Figure 2C), each rat had peak BG beta frequency slightly below 20 Hz (range: 17.9–19.5 Hz) with cortical frequency consistently a touch higher (18.4 Hz to 20.4 Hz). If beta oscillations represent a distinct, network-wide coordinated BG state, this … Continue reading →

The Shh gradient rapidly stimulated the repulsion of axons with turning commencing within 1 hr of application of the gradient, indicating that the effect of Shh is direct. Quantification of the angle turned (Figure 3D) indicated that axons in a control gradient … Continue reading →