Monthly Archives: March 2019

However, these haemolytic assays are all cumbersome and difficult to standardize. Several enzyme-linked immunosorbent assays (ELISA) for the assessment of the functional activity of the complement activation pathways have been described, but the use of these assays in routine clinical … Continue reading →

Figure 4. Overexpression huBCL-2 and huMCL-1 in CD8αα+ iIELs from WT and Il15ra−/− mice Figure S5. Bcl-2 and Bim affect CD8αα+ iIELs survival during in spleen compartment of Il15ra−/− recipients. Figure S6. IL-15-mediated ERK activation in CD8αα+ iIELs is unlikely … Continue reading →

To determine whether rSj16 could induce regulatory T cells in vitro, spleen mononuclear cells were isolated from the naïve mice and cultured in the presence of rSj16, SEA or OVA, respectively. Four days later, cells were analysed by flow cytometry … Continue reading →

This defect in adhesion is accompanied by reduced T-cell proliferation and interleukin-2 production.51–53 Defects in T-cell selection have also been documented in certain ADAP-deficient transgenic models expressing a single TCR.54 ADAP binds directly to Src kinase-associated protein of molecular weight … Continue reading →

Results:  Recipients receiving shipped renal allografts were more likely to be highly sensitized with previous grafts and/or higher panel reactive antibodies levels with significantly longer graft ischaemic time compared to local allografts. Regardless of the HLA mismatches, the risk of … Continue reading →

No patients on placebo plus tamsulosin reported retention. Patients on solifenacin plus tamsulosin vs placebo plus tamsulosin showed larger reductions in frequency, but not of statistical significance. However, there were no statistically significant reductions in urgency. Patient-reported outcome measures showed … Continue reading →

In addition, as our study suggests, IL-15 is unlikely to be the only stimulus that determines the extent of NK-cell expansion. We found that stimulation with IL-15 had a profound impact on NK cells, but that the kinetics and the … Continue reading →

Uric acid crystals and calcium pyrophosphate dihydrate, the causative agents of gout and pseudogout, respectively, were the first crystalline molecules shown to activate the NLRP3 inflammasome 21. Another endogenous molecule, fibrillar amyloid-β, associated with the pathogenesis of Alzheimer’s disease, also … Continue reading →

We intravitally measured mesenteric lymphatic diameter and contraction frequency, as well as lymphocyte velocity and density before, during, and after infusion. A 10-fold increase in lymphocyte velocity (0.1–1 mm/s) and a sixfold increase in flow rate (0.1–0.6 μL/min), were observed post infusion, … Continue reading →

However, IL-17-producing γδ T cells have been detected in both IL-2- and CD25-deficient mice, indicating that IL-2 may play a role in maintenance rather than induction of IL-17-producing γδ T cells. However, there may also be an antagonistic role for … Continue reading →