Apart from a structured monthly phone call, there was physician-led medical selleckbio support available 24 hours a day, 7 days a week. Intervention
was provided based on set standards on an ongoing basis. A total of 710 patients were randomized to the monitoring system and usual care. Compliance in the intervention arm was high — 81% Inhibitors,research,lifescience,medical had at least 70% of daily data transmission. Follow-up at 26 months (on average) showed no difference in overall mortality, cardiovascular mortality, or hospitalizations. In addition to weight, the TEN-HMS study also monitored blood pressure, heart rate, and rhythm (with a single-lead electrocardiogram) twice daily and transmitted into a hub connected to a conventional telephone line, which then transmitted information through a central web server to each investigator site. The study was halted early due to a selleck chem Trichostatin A significantly higher mortality in the usual care group (reflecting a high-risk population) when compared to either nurse telephone support Inhibitors,research,lifescience,medical or the above-described telemonitoring system. There was
no significant difference in outcomes between the latter two groups. The patient contact time was significantly lower in the usual-care arm, and evidence-based medications were more frequently used in both the nurse-based support and telemonitoring arms. Inhibitors,research,lifescience,medical Though telemonitoring increased hospitalization for HF, it decreased length of stay, probably due to a higher comfort level of healthcare providers being able to monitor patients at home. Finally, the Specialized Primary and Networked Care in Heart Inhibitors,research,lifescience,medical Failure-II (SPAN CHF-II) trial evaluated the impact of automated home monitoring added to a disease management program and found no added benefit for providing Inhibitors,research,lifescience,medical daily medication prompts, recordings of weight, vital signs, and symptoms.12 Though the published meta-analyses show a positive outcome for telemonitoring, they do not include the recent experience from the above-mentioned Tele-HF, TIM-HF,
and SPAN-CHF II trials. At this time, the strength of evidence in favor of these interventions is unclear. Moreover, it is difficult to interpret the meta-analyses of studies that had varied interventions clubbed under telemonitoring. Monitoring With Specially Designed Cilengitide Wearable and Implantable Technology The focus of telemonitoring has centered on predicting acute decompensation episodes that are typically associated with fluid congestion and require optimization of diuretic therapy. The sine quo non for this process is to identify the parameter that best predicts fluid congestion. As mentioned previously, the sensitivity and specificity of weight as a reflection of total body water is not accurate.
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