1,25 To the best of our knowledge there is a little reliable information related to the CVDs and tropical infections. Recently, increasing population and travelling from tropical low-income areas to high-income industrialized countries has led to increased presentation of the above mentioned disorders in the developed countries.26,27 Malaria There are about 400 to 500 million cases of malaria around the world with 30% are located in Asia and the major Inhibitors,research,lifescience,medical remainder in Africa.28 Malaria itself causes 0.5 to 2.5 million deaths each year. Cerebral malaria (CM) which is the most severe
complication of malaria is an acute and diffuse encephalopathy associated with Plasmodium falciparum infection. Cerebral malaria could be responsible for
up to 10% of strokes in endemic regions.29 Neurological focal signs due to vascular Inhibitors,research,lifescience,medical injuries are rare, but may produce severe outcome. Early and adequate treatment is effective way of preventing permanent sequel. The precise mechanism is not known, but the histopathologic hallmark of cerebral malaria is vascular engorgement with infected and non-infected red Inhibitors,research,lifescience,medical blood cells with parasites, metabolic disturbances, and host immune responses.30 Quinine is the mainstay of treatment, and has to be prescribed with adequate loading dose (20 mg/kg of the dihydrochloride salt infused over 4 hours) to ensure that a parasiticidal concentration is reached in the blood.31 Artemisnin derivatives are also good alternatives. Artemether is used intramuscularly, and artesunate is used intravenously, which may decrease the mortality secondary to CM.32,33 Fluid, electrolyte Inhibitors,research,lifescience,medical balance and acid-base correction are important cornerstones of treatment. Dexamethasone may prolong coma in the survivors and should not be used in CM.34 Tuberculosis Central Inhibitors,research,lifescience,medical nervous system tuberculosis (TB) is a serious type of extra-pulmonary TB, and continues to be an important public health problem in developing countries. World Health Organization estimates that one-third of the world’s population is infected with Mycobacterium tuberculosis (MTB), with the highest prevalence
of tuberculosis in Southeast Asia.35 Different forms of CNS tuberculosis may cause motor deficit. These are tuberculous myelopathy,36 intramedullaary tuberculoma,37 syringomyelia,36 radiculomyelitis,38 and tuberculous meningitis (TBM),39 however, the main cause of stroke is TBM. Stroke occurs in 15-75% of patients with TBM occurs, especially in advance Methisazone stage of the disease with severe illness. The majority of strokes may be asymptomatic, because of being in a silent area or the patient is in deep coma.40 In all cases caused by MTB, the bacterium settled in the lungs and disseminated to the nervous system through the hematogenous system. SB590885 chemical structure Rupture of rich nodules into the subarachnoid space is the beginning phase of meningitis. It induces lymphocytic infiltration around the meningeal blood vessels, and finally causes arteritis in almost all cases and cerebral infarction.
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