Noticeably, BIs are consistently fused in sarcoma (FUS) positive. NIFIs are by definition immuno-positive for class IV IFs including three BTK inhibitor concentration NF triplet subunit proteins and α-internexin but negative for tau, TDP-43, and α-synuclein. In NIFID cases several types of inclusions have been identified. Among them, hyaline conglomerate-like inclusions are the only type that meets the above immunohistochemical features of NIFIs. This type of inclusion appears upon HE staining as multilobulated, faintly eosinophilic or pale amphophilic spherical masses with a glassy appearance. These hyaline conglomerates appear strongly argyrophilic, and robustly and consistently immuno-positive
for IFs. In contrast, this type of inclusion shows no or only occasional dot-like FUS immunoreactivity. Therefore, BIs and NIFIs are distinct from each other in terms of morphological, tinctorial and immunohistochemical features. However, basophilic inclusion body disease (BIBD) and NIFID are difficult High Content Screening to differentiate clinically. Moreover, Pick body-like inclusions, the predominant type of inclusions seen in NIFID, are considerably similar to the BIs of BIBD in that this type of inclusion is basophilic, poorly argyrophilic, negative for IFs and intensely immuno-positive for FUS. As BIBD
and NIFID share FUS accumulation as the most prominent molecular pathology, whether these two diseases are discrete entities or represent a pathological continuum remains a question to be answered. “
“An 84–year-old man with rheumatoid arthritis (RA) treated with methotrexate, developed progressive confusion and cerebellar symptoms, and died approximately 2 months later. Neuropathological examination revealed progressive multifocal leukoencephalopathy (PML) involving the cerebellum and brainstem. The affected tissues
pheromone displayed intense infiltrations by CD8+ T-cells and microglia. JC virus was localized in oligodendroglia and cerebellar granule cells. This case illustrates unusual localization of inflammatory PML in a patient with RA treated with methotrexate. Progressive multifocal leukoencephalopathy (PML) is a demyelinating, usually non-inflammatory disorder of the CNS caused by reactivation of a latent JC virus (JCV), in the setting of immunosuppression.[1-4] The most frequent underlying conditions are HIV/AIDS, myelo- and lymphoproliferative disorders, autoimmune and chronic granulomatous diseases, as well as the use of immunomodulatory medications.[1-4] Among autoimmune disorders, the most common is systemic lupus erythematosus.[5-7] PML as a complication of rheumatoid arthritis (RA) treated with immunosuppressive medication is rare.[8-19] We present a patient with RA treated with methotrexate who developed an uncommon form of inflammatory PML limited to the infratentorial compartment.
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