Quantitative immunocytochemistry is employed to demonstrate that A beta(1-40) preparations containing isolated soluble aggregates elicit the most pronounced activation and nuclear translocation of NF-kappa B. This rapid and transient response is observed down to physiological A beta concentrations
and parallels phenotypic changes in endothelial monolayers that are selectively elicited by soluble A beta(1-40) aggregates. While monomeric Selleck CYT387 and fibrillar preparations of A beta(1-40) also activated NF-kappa B, this response was less pronounced, limited to a small cell population, and not coupled with phenotypic changes. Soluble A beta(1-40) aggregate stimulation of endothelial monolayers for adhesion and subsequent transmigration of monocytes as well as increases in permeability were abrogated by inhibition of NF-kappa B activation. Together, these results provide additional evidence indicating a role for soluble A beta aggregates in the activation of the cerebral microvascular endothelium and implicate the involvement of NF-kappa B signaling pathways in A beta stimulation of endothelial dysfunction associated
with AD.”
“A new theoretical approach is proposed to explain the dose, dose rate and temperature sensitivity of the radiation-induced absorption (RIA) in glasses. In this paper, a beta(th)-order dispersive kinetic model is used to simulate the growth of the density of color centers in irradiated glasses. This model yields an explanation for the power-law dependence on dose and dose rate usually observed for the RIA in optical fibers. It also leads to an Arrhenius-like selleck chemical relationship between the RIA and the glass temperature during irradiation. With a very limited number of adjustable parameters, the model succeeds in explaining, with SRT2104 mouse a good agreement, the RIA growth of two different optical fiber references over wide ranges of dose, dose rate and temperature. (C) 2010 American Institute of Physics. [doi:10.1063/1.3503370]“
“Increasing health care cost is a major concern in developing world. Patients
are affected by the high pricing of drugs and though the symptoms improve the poor patient compliance sets in if the regimen is heavy on the pocket of the patient. Therefore, concept of Pharmacoeconomics are essential for physicians to prescribe individualized drug therapy based on essential drug concept, STEP as well as rational utilization of drug(R.U.D.) criteria, with minimal costs to improve the cost-effectiveness of the drug therapy. Sensitizing medical undergraduates on pharmacoeconomics during second year training will inculcate the habit of prescribing cost effective medicine and cost consideration throughout their medical career and will decrease the monitory burden on the patient and the society. A module on PE was prepared and implemented in tertiary medical hospital for second year medical undergraduates.
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