, 2002). It could therefore be possible that performance was dictated by strategy adoption, but whether
strategy adoption in older age is constrained by brain integrity or vice versa is an interesting question that could be addressed in future work. In summary, the current study provides a novel perspective on two competing theories that have arisen from the fMRI literature, using neurostructural data (structural and diffusion MRI). We found little evidence supportive of the hypothesis that poorer performers exhibit a breakdown in cross-hemisphere inhibition of the right PFC by the left PFC via the genu of CC. Instead, we identified divergent neural correlates for verbal memory recall between high and low performers in older age, indicative of a partially compensatory role of the right DLPFC among individuals who are performing more poorly, possibly to supplement changes in posterior Volasertib mw and left fronto-lateral functioning
(Davis et al., 2007 and Park and Reuter-Lorenz, 2009). Future studies aiming to improve our understanding of this aspect of brain ageing and its cognitive sequelae will ideally increase participant see more numbers and combine structural, diffusion and fMRI modalities with an examination of strategy adoption and a wider view of other brain regions that may contribute to verbal memory ability. This research and LBC1936 phenotype collection were supported by Age UK (The Disconnected Mind project). It was undertaken in the Centre for Cognitive Ageing and Cognitive Epidemiology (http://www.ccace.ed.ac.uk)—part of the cross council Lifelong Health and Wellbeing Initiative—which is supported by funding from the UK’s Biotechnology and Biological Sciences Research Council, the Economic and Social Research Council and the Medical Research Council (MR/K026992/1). Brain imaging took
place in the University of Edinburgh in the Brain Research Imaging Centre (http://www.bric.ed.ac.uk) which is part of Rebamipide the SINAPSE collaboration (http://sinapse.ac.uk). We thank the Lothian Birth Cohort 1936 (LBC1936) members who took part in this study, radiographers at the Brain Research Imaging Centre, nurses at the Wellcome Trust Clinical Research Facility, Laura Pidgeon for useful discussion on the lateralisation of memory processes and LBC1936 research associates who collected and entered some of the cognitive data used in this manuscript. “
“Recent functional neuroimaging studies on language (Friederici, 2011 and Vigneau et al., 2006) investigating syntactic, semantic and verbal working memory processes identified circumscribed activations located within the two classical language regions, i.e., Broca’s region in the inferior frontal gyrus (IFG) and Wernicke’s region in the superior temporal gyrus. Within Broca’s area the dorsal part of the left pars opercularis (44d) processes hierarchically structured syntax (e.g.
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