Results: Two hundred and five miRNAs were differentially expressed in the sera from acute pancreatitis patients in comparison to those from healthy controls. Between severe and mild acute pancreatitis patients, there were nine differentially expressed miRNAs. Further validation revealed that the expression of miR-92b, miR-10a, and miR-7 can distinguish acute pancreatitis patients from health controls. In addition, miR-551b-3p level can differentiate severe and mild check details acute pancreatitis and is significantly correlated with the serum calcium level and presence of complications. Conclusion: The serum levels of miR-92b, miR-10a, and
miR-7 may be useful in assisting acute pancreatitis early detection and miR-551b-3p may help determining disease severity. Our study also suggested that these miRNAs may play a role in acute pancreatitis pathogenesis. Key Word(s): 1. microRNA; 2. Acute Pancreatitis; 3. Diagnosis; 4. Prognosis; Presenting Author: TAO YU Additional Authors: NVP-BGJ398 purchase JIE-YAO LI, LI-NA ZHAO, QI-KUI CHEN Corresponding Author: QI-KUI CHEN Affiliations: Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University Objective: Enteral nutrition is increasingly advocated in the treatment of acute pancreatitis,
but its timing is still controversial. The aim of this meta-analysis was to find out the feasibility of early enteral nutrition within 48 hours of admission and its possible advantages. Methods: We searched PubMed, EMBASE Databases, Web of Science, the Cochrane library, and scholar.google.com for all the relevant articles about the effect of enteral nutrition initiated within 48 hours of admission on the clinical outcomes of acute pancreatitis from inception to December 2012. Eleven studies containing 775 patients with acute pancreatitis were analyzed. Results: Results from a pooled analysis of all the studies demonstrated that early enteral nutrition was associated with significant
reductions in all the infections as a whole (OR 0.38; 95%CI 0.21–0.68, P < 0.05), in catheter-related septic complications (OR 0.26; 95%CI 0.11–0.58, P < 0.05), in pancreatic infection (OR 0.49; 95%CI 0.31–0.78, P < 0.05), in hyperglycemia (OR 0.24; 95%CI 0.11–0.52, P < 0.05), in the length of hospitalization (mean difference −2.18; many 95%CI −3.48-(-0.87); P < 0.05), and in mortality (OR 0.31; 95%CI 0.14–0.71, P < 0.05), but no difference was found in pulmonary complications (P > 0.05). The stratified analysis based on the severity of disease revealed that, even in predicted severe or severe acute pancreatitis patients, early enteral nutrition still showed a protective power against all the infection complications as a whole, catheter-related septic complications, pancreatic infection complications, and organ failure that was only reported in the severe attack of the disease (all P < 0.05).
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