However, the expressions of Proteases inhibitor Hsp90-beta and annexin A1 did not correlate with other clinicopathologic factors such as gender, age, smoking imaging, and pleural invasion. Table 4 Correlation between clinico-pathological features and the expressions of Hsp90-beta and annexin A1 in lung cancer Parameter Group
N Expression of Hsp90-beta Expression of annexin A1 Low (%) Moderate (%) High (%) χ 2value Pvalue Low (%) Moderate (%) High (%) χ 2value Pvalue Gender Male 73 12(16.4) 22(30.1) 39(53.4) 4.49 0.105 18(24.7) 26(35.6) 29(39.7) 5.09 0.078 Female 23 2(8.7) 3(13) 18(78.3) 2(8.7) 6(26.1) 15(65.2) Ages <60 54 8(14.8) 13(24.1) 33(61.1) 0.251 0.882 8(14.8) 20(37)
26(48.1) 2.798 0.247 ≥60 42 6(14.3) 12(28.6) 24(57.1) 12(28.6) 12(28.6) 18(42.9) Smoking 0 37 3(8.1) 6(16.2) 28(75.7) 8.28 click here 0.082 5(13.5) 10(27) 22(59.5) 3.856 0.248 0.1–40 12 1(8.33) 5(41.67) 6(50) 2(16.7) 5(41.7) 5(41.7) >40 47 10(21.3) 14(29.8) 23(48.9) 13(27.7) 17(36.2) 17(36.2) Histology LAC 39 8(20.5) 9(23.1) 22(56.4)★ 8.16 <0.05 7(17.9) 9(23.1) 23(59)▴ 7.513 <0.05 LSCC 41 5(12.2) 13(31.7) 23(56.1)★ 10(24.4) CBL0137 mw 19(46.3) 12(29.3)▴ SCLC 11 1(9.1) 1(9.1) 9(81.82)★ 2(18.2) 2(18.2) 7(63.6)▴ Others 5 0(0) 2(40) 3(60) 1(20) 2(40) 2(40) Pathological grade Poorly 26 1(3.8) 4(15.4) 21(80.8) 31.26 <0.0005 2(7.7) 2(7.7) 22(84.6) 38.26 <0.0005 Moderately 33 1(3.03) 12(36.36) 20(60.61) 5(15.2) 21(63.6) 7(21.2) Well 22 11(50) 6(27.3) 5(22.7) 10(45.5) 5(22.7) 7(31.8) Undifferentiated 15 1(6.67) 3(20) 11(73.33) 3(20) 4(26.7) 8(53.3) Lymphatic invasion
N0 41 12(29.3) 18(43.9) 11(26.8)★★ 31.02 <0.0005 17(41.5) 13(31.7) 11(26.8)▴▴ 19.97 <0.0005 N1 40 1(2.5) 5(12.5) Immune system 34(85) ★★ 2(5.5) 17(34.5) 21(60) ▴▴ N2 11 0(0) 2(18.2) 9(81.8) ★★ 1(9.1) 1(9.1) 9(81.82)▴▴ N3 4 0(0) 0(0) 4(100) ★★ 0(0) 0(0) 4(100) ▴▴ hydrothorax Absent 82 13(15.9) 23(28) 46(56.1) 2.51 0.285 18(22) 29(35.4) 35(42.7) 2.25 0.324 Present 14 1(7.1) 2(14.3) 11(78.6) 2(14.3) 3(21.4) 9(64.3) T stage T1 – T2 57 11(19.3) 22(38.6) 24(42.1) 14.72 0.001 17(29.8) 23(40.4) 17(29.8) 14.83 0.001 T3 – T4 28 2(7.1) 2(7.1) 24(85.7) 1(3.6) 7(25) 20(71.4) Unavailable 11 1(9.1) 1(9.1) 9(81.82) 2(18.18) 2(18.18) 7(63.64) pTNM IB 3 1(33.3) 2(66.7) 0(0)● 11.449 0.022 0(0) 3(100) 0(0)●● 9.97 0.008 IIA-IIB 53 10(18.9) 19(35.8) 24(45.3)● 16(30.2) 20(37.7) 17(32.1)●● IIIA-IIIB 25 2(8) 3(12) 20(82)● 2(8) 6(24) 17(68)●● IV 4 0(0) 0(0) 4(100)● 0(0) 1(25) 3(75)●● Unavailable 11 1(9.1) 1(9.1) 9(81.82) 2(18.18) 2(18.18) 7(63.64) Imaging Central 43 5(11.63) 15(34.88) 23(53.49) 2.68 0.261 11(20.9) 16(41.9) 16(37.2) 2.07 0.356 Ambient 49 9(18.37) 10(24.49) 30(57.14) 8(20.4) 16(32.7) 25(46.
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