, 1991, Terrosi et al , 2009 and Valassina et

al , 2003),

, 1991, Terrosi et al., 2009 and Valassina et

al., 2003), Marches (Nicoletti et al., 1991), Siena (Braito et al., 1998, Cusi et al., 2010 and Valassina et al., 1996), Sicily (Amodio et al., 2012, FK228 chemical structure Calamusa et al., 2012, Colomba et al., 2012 and Valassina et al., 1996), Emilia Romagna (Portolani et al., 2002 and Vocale et al., 2012), Piedmont (Valassina et al., 2003), Umbria (Baldelli et al., 2004 and Francisci et al., 2003), Naples (Di Nicuolo et al., 2005), Sardinia island (Venturi et al., 2007), Elba island (Gabriel et al., 2010 and Sonderegger et al., 2009), and Calabria (Greco et al., 2012). Seroprevalence studies conducted among voluntary subjects registered at the National Health Laboratories in Sicily, provided evidence of the circulation of Sicilian or Sicilian-like viruses (Calamusa et al., 2012) which had also previously been implicated in an earlier study

among ovine species (Castro et al., 1976). Sicilian virus was reported not to be circulating in Tuscany where Toscana virus is the main cause of sandfly fever (Cusi et al., 2013). Arbia virus which was isolated from P. perniciosus in Tuscany was considered to be a strain or subtype of Salehebad virus ( Verani et al., BMN 673 1988). Subsequently another virus, Adria virus was added. There are no data suggesting that Arbia virus is capable of infecting humans, and causing disease. The first case of Toscana virus infection in France was reported in a German tourist (Dobler et al., 1997) and cases with and without meningitis

C1GALT1 were subsequently reported (Hemmersbach-Miller et al., 2004 and Peyrefitte et al., 2005). One case of encephalitis was reported (Doudier et al., 2011). Virus isolation was achieved from human samples and from P. perniciosus sandflies in Marseille ( Charrel et al., 2007). Detection of Toscana virus RNA from Sergentomyia minuta was also reported ( Charrel et al., 2006). Two seroprevalence studies conducted on blood donors from Marseille and southeastern France, respectively, provided similar results and demonstrated that Toscana virus circulates actively in southeastern France (12–14% of blood donors possessed anti-Toscana virus IgG) ( Brisbarre et al., 2011 and De Lamballerie et al., 2007). In the latter study, 8.7% of sera collected in Corsican blood donors were anti Toscana virus IgG-positive. Low seroprevalence rates of Sicilian virus antibodies were reported in the southwestern France (2%) and in Marseille (1%) among blood donors (Bichaud et al., 2011 and Enjalbert et al., 1969). Moreover, a serosurvey in wild mammals reported 0.3% seropositivity for Sicilian virus antibodies (Le Lay-Rogues et al., 1987). Massilia virus, which is most closely related to viruses in the SFNV species, was isolated from P. perniciosus in Marseille and Nice and reported to circulate in southeastern France ( Charrel et al., 2009). The first case of Toscana virus infection in Spain was reported from Catalonia in a Swedish tourist (Eitrem et al., 1991a).

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