, 2006). However, it is difficult to distinguish effects of adaptation that are inherited from earlier stages from those that are specific to a cortical area, and in some cases adaptation appears to proceed unchanged from one cortical area to the next (Gardner et al., 2005). In the visual system, a promising method to overcome this difficulty is to measure the spatial selectivity of adaptation, exploiting the fact that earlier stages have smaller receptive fields than later stages (S. Harrison and J.Y. Larsson, 2012, Soc. Neurosci., abstract). In the view of adaptation that emerges from these studies, each stage inherits passively the adaptation provided by the previous stages, without
modifying its input rules to help this adaptation or to counteract it. Each stage can then add its own form AG14699 of adaptation. Doxorubicin molecular weight The goals of this adaptation may differ in different brain regions. For instance, in V1 the goal could be to maintain homeostatic balance across groups of neurons (Benucci et al., 2013). A similar view has emerged from psychophysical measurements of adaptation. In particular, there is evidence that perceptual effects of motion adaptation on perceived velocity arises from a cascade of two mechanisms,
one that knows about visual motion and one that does not (Stocker and Simoncelli, 2009). More generally, our view agrees with the general idea that perception arises from an encoder-decoder cascade, in which the decoder is not aware of the adaptation that occurred in the encoder (Seriès et al., 2009). Our results identify in the LGN responses the cause for the changes Resminostat in V1 spatial tuning, but they do not reveal the mechanisms underlying the changes seen in LGN. LGN neurons with receptive fields near the adapting stimulus were reduced in gain relative to the rest. This effect could be inherited
from retina or be strengthened in LGN, as both regions show evidence for spatial adaptation (Solomon et al., 2004). However, LGN neurons with receptive fields further away saw an increase in gain. This increase may be due to the slight decrease in probability of stimulation that these neurons experienced in the biased stimuli, or it may be due to adaptation desensitizing their nonclassical suppressive field (Bonin et al., 2005, Camp et al., 2009 and Solomon et al., 2002). Adaptation can radically transform the neural signal as it cascades through the neural hierarchy. We expect this effect to appear wherever the tuning curves of one area build on the population responses of its feedforward inputs. For instance, we would expect similar effects in other sensory domains such as audition. Here, adaptation to a particular sound frequency might scale response magnitude subcortically but shift tuning curves in subsequent stages. The results obtained here, therefore, may apply to multiple brain regions and modalities.
Related posts:
- Effects Effects of EGFR-specific siRNA on target expression and m
- Response bias has been demonstrated to adapt to all four types of
- 2 The PSAEFI in Brazil has certain features that distinguish it
- g , Vigneau et al 2006, 2011) in these same children With regar
- Samples were gated to distinguish compact debris and doublets by