22 Due to a higher negative charge on cell surface, the interaction between Gram-negative bacteria and positive charge CSNCs was definitely stronger than that of Gram-positive bacteria. In this work, porous chitosan/silver nanocomposite film was successfully synthesized and characterized by
FTIR, XRD and HRSEM techniques. The resulting nanocomposite film not only biocompatible in nature, but also provide excellent stability for a sustained release of nanoparticles for antibacterial applications. The developed porous nanocomposite film has exhibited superior antibacterial properties against Gram-negative bacteria compared to Gram-positive bacteria. Further studies on the biocidal influence of this nanomaterial on other Gram-negative and Gram-positive bacteria are
necessary in order to fully evaluate its possible use as a new BIBW2992 mouse bactericidal material. All authors have none to declare. selleck chemicals “
“Uncontrolled acid secretion and ulceration of gastric mucosa due to several reasons have posed serious problems to the human health all over the globe.1 Many natural products and modern synthetic drugs have been used to treat the gastric ulcer disease but so far a complete cure has not been discovered and exploration of new anti-ulcer drugs has remained a field of active research.1 Since centuries a number of medicinal plants have been used in the PAK6 treatment of gastric ulcer.2 The modern drugs have also been used
to treat the disease in different combinations as double, triple and quadruple therapy regimens.3, 4 and 5 In spite of all these developments, side/adverse effects and recurrence of gastric ulcer disease occurs even after long-term therapies.6, 7 and 8 Therefore, the treatment of this disease has continued to be the big therapeutic challenge to the pharmacologists. In an effort to further search curative and safe agents for the treatment of gastric ulcer in the indigenous medicinal plants, present study was undertaken. For this purpose, a highly reputed and quite frequently used medicinal plant in the traditional medicine, Nigella sativa (Kalonji) seed was selected. In our previous study, we reported that the ethanol extract, ethyl acetate fraction (NS-EA) and purified fraction (NS-EA 51) of N. sativa seed protected the rats against gastric ulcers, induced by indomethacin. 9 Therefore, it was planned to test the purified fraction of N. sativa seed (NS-EA 51) for its anti-ulcer effects in the histamine plus PL and hypothermia-restrain stressed models. N. sativa seeds were purchased locally from herbal dealer in Gujranwala, Pakistan. The plant material was authenticated and compared with its standard in the herbarium maintained by Department of Botany, University of Agriculture, Faisalabad, Pakistan. A specimen (NS. Ph.
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