5 Lactobacilli and bifidobacteria are the primary probiotic bacteria which are associated with cholesterol reduction, although comparable effect may be produced by other lactic acid bacteria, such as enterococci.11 It has also been reported that oral administration of heat killed Lactobacillus casei to non-obese diabetic (NOD) mice reduces the incidence of diabetes, but Inhibitors,research,lifescience,medical the mechanism
underlying this effect has not been clarified.12,13 This study was designed to determine the effect of probiotics on lipid profile, glycemic control, insulin level, oxidative stress and inflammatory markers in patients with type 2 diabetes. Patients and Methods This single-blinded clinical trial comprised 40 patients with type 2 diabetes recruited from medical clinic affiliated with Shiraz University of Medical Sciences (SUMS) Shiraz Iran. Diabetic patients with fasting blood glucose ≥126 mg/dl, aged from 25 to 65 years, and diagnosed as having diabetes for less than 15 years were eligible for the study. Exclusion criteria were current smokers, subjects on non-steroidal Inhibitors,research,lifescience,medical anti-inflammatory drugs and multivitamin, as well as patients undergoing hormone replacement therapy, and those with any chronic diseases involving kidney, liver, and lung. The research was approved by the Ethics committee of SUMS, and written
informed consent was obtained from all patients Inhibitors,research,lifescience,medical prior to commencement Inhibitors,research,lifescience,medical of the study. Subjects were initially studied during a screening visit Study Design After an overnight fast starting from 8 pm in previous evening baseline plasma samples were collected and analyzed for triglyceride, total cholesterol, LDL-C, HDL-C, glucose, insulin, malondialdehyde, hs-CRP and IL-6. Using balanced block buy LY294002 random sampling, subjects were then divided into two groups of intervention (probiotics) and placebo. Patients in
the intervention or treatment group received 1500 mg probiotic capsules Inhibitors,research,lifescience,medical twice daily, after lunch and evening meal for 6 weeks. The lactobacillus probiotics contained L. acidophilus, L. bulgaricus, L. bifidum, and L. casei. Mephenoxalone Patients in placebo group received 1500 mg capsules containing 1000 mg magnesium stearate twice daily for six weeks. Magnesium stearate is generally considered safe for human consumption at levels below 2500 mg/kg per day.14 According to the FDA’s subcommittee report on GRAS (generally recognized as safe) substances (SCOGS), adding magnesium stearate directly to human food was affirmed as GRAS.15 After six weeks of experiment, fasting blood samples were collected and analyzed for all aforementioned parameters. Methods of Data Gathering Demographic data including age, sex, weight, height, body mass index (BMI), and waist to hip ratio (WHR) were measured before and after the intervention. Auto-analyzer Bio-Systems A-25 was used to determine the lipid profile and blood glucose concentration.
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