627 (P = 0.045; 95% CI, 0.503–0.750), 0.540 (P = 0.523; 95% CI, 0.414–0.666) and 0.673 (P = 0.006; 95% CI, 0.557–0.790), respectively, Alpelisib order indicating that IP-10 concentration was a better pretreatment predictor of severe liver inflammation than AST and ALT levels. The IP-10 concentration was significantly lower in the 38 IFN-treatment-naïve patients (median, 331.86 pg/mL; range, 151.35–1333.57) than in the 39 patients
who relapsed (median, 529.29 pg/mL; range, 169.58–4297.62; P = 0.005) and the 20 non-responders (median, 583.42 pg/mL; range, 278.38–1768.81; P = 0.001). IP-10 concentrations, however, did not differ significantly in relapsers and non-responders (P = 0.154) (Fig. 3a). IL28B genotype (rs8099917) was tested in 94 patients, including 67 with IL28B TT and 27 with IL28B non-TT. In terms of IP-10 level, there was no significant difference between patients with IL28B TT (median, 414.67 pg/mL; range, 169.58–4297.62) and those with IL28B non-TT patients (median, 534.97 pg/mL; range, 151.35–1768.81) (P = 0.294) (Fig. 3b). Core amino acid 70/91 was tested in 73 patients. In terms of core 70, they included
wild type in 45 patients, mutant type in 21, competent type in two and equivocal in five. In terms of core 91, they included wild type in 47 patients, mutant type in 20, competent type in one and equivocal in five. In terms of IP-10 level, there was no significant difference between patients with core 70 wild type (median, MG-132 order 455.05 pg/mL; range, 151.35–1490.87) and those with
core 70 mutant type (median, 533.44 pg/mL; range, 190.76–1768.81) MCE (P = 0.286). Similarly, patients with core 91 wild type did not have significantly higher IP-10 level (median, 531.74 pg/mL; range, 190.76–1768.81) than those with core 91 mutant type (median, 374.97 pg/mL; range, 151.35–765.16) (P = 0.058). In three patients (3.1%), RVR was not evaluated because of missing data. Thus, RVR was evaluated in 94 patients, 71 (75.5%) of whom achieved RVR. Eighty-one (83.5%) of 97 patients achieved ETR. In two patients, SVR12 was not evaluated: one patient discontinued treatment because of a PEG IFN-related psychiatric disorder, and one selected to discontinue treatment, with both lost to follow up. Of the 95 evaluable patients, 71 (74.7%) achieved SVR12. Nineteen patients (19.6%) discontinued all study drugs: three for renal dysfunction; two each for severe general fatigue and loss of appetite, grade 3 or higher rash and patient discretion; and one each for thyrotoxicosis, severe anemia, deterioration of liver function, gastrointestinal bleeding, pneumonia, acute heart failure, HCC development, PEG IFN-related psychiatric disease and an unexpected accident. Baseline serum IP-10 concentration was significantly lower in the 71 patients who achieved RVR (median, 394.64 pg/mL; range, 151.35–4297.62) than in the 23 who did not (median, 583.55 pg/mL; range, 209.66–1768.81) (P = 0.001).
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