In fact, if the modulation exerted by eye position on visual parietal neurons (for a review see Andersen & Buneo, 2002) might favour the transformation of target location from retinal into body-centred coordinates, hand position signals are essential to compute the corresponding hand movement trajectory. As such, they exert a profound influence on encoding movement direction in the motor (Caminiti et al., 1990), premotor (Caminiti et al., 1991;
Burnod et al., 1992) and PPC (Lacquaniti et al., 1995; Battaglia-Mayer et al., 2000, 2005; Ferraina et al., 2009) areas. Similar trends of functional properties exist across the different architectonic areas http://www.selleckchem.com/products/gsk126.html (Pandya & Seltzer, 1982; Rozzi et al., 2006) of the flat exposed part of IPL, as gradients have been reported for eye-related signals across areas 7a and LIP (Barash et al., 1991), the
first containing mostly post-saccadic neurons, the latter containing mainly pre-saccadic cells. A gradual transition of functional properties of neurons across the areas of the convexity of the IPL was first observed by Hyvärinen (1981) and recently confirmed and extended by Rozzi et al. (2008). An additional and crucial feature of the network emerges when considering that frontal and parietal areas displaying similar neuronal activity-types are linked by reciprocal association connections (Johnson et al., 1996; Chafee & Goldman-Rakic, 2000; LDE225 supplier Marconi et al., 2001), indicating that the parietofrontal association system probably both reflects and imposes functional specialization on cortical regions within the network. As a consequence, Parvulin in the parietal and frontal cortex different forms of visuomotor activities involving the coordination of eye–hand movements might emerge as a result of a progressive match of
spatial information representing the positions of the two effectors and their relation to visual targets. This match of signals could be based on a recursive signalling operated through ipsilateral association connections and refined locally by intrinsic connectivity, i.e. by short intracortical connections (see Burnod et al., 1999 for a theoretical frame). This interpretation is consistent with a number of experimental observations and with the predictions of network modelling. Experimental results (Johnson et al., 1996; Chafee & Goldman-Rakic, 2000) indicate that association connections are likely to confer common physiological properties on frontal and parietal neurons during behaviour. These connections are also likely to play a major role in shaping network dynamics that are a product of both input activation and previous learning, as a Bayesian collective decision process (Koechlin et al., 1999). Furthermore, populations of units that combine retinal, hand and eye signals, and are linked by recurrent excitatory and inhibitory connections, are necessary to shape the directional tuning properties of SPL neurons (Mascaro et al., 2003).
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