Against ESBL-producing K. pneumoniae, imipenem (88.9%-96.4%) and tigecycline (85.1%-100%) demonstrated the highest rates of activity. Tigecycline demonstrated excellent activity against clinically relevant Cyclosporin A resistant organisms.”
“Early endothelial outgrowth cells (eEOCs) protect mice from acute kidney injury (AKI). Peroxisome proliferator-activated
receptor-alpha (PPAR-alpha) has been shown to mediate renoprotective effects under different experimental conditions. The aim of the study was to investigate consequences of fibrate treatment of murine eEOCs in a cell-based therapeutic approach to AKI.
Male C57/Bl6N mice, subjected to unilateral renal ischemia (40 min) post-uninephrectomy, were systemically injected with 0.5 x 10(6) untreated or fenofibrate
(FF 1, 5, 10 or 50 mu m)/clofibrate (CF 1 mm) pretreated syngeneic murine eEOCs. Renal function and morphology were analyzed 48 h later. Cellular consequences of eEOC treatment with fibrates (FF 1, 5, 10, 50 mu m, CF 1 mm) were evaluated using different in vitro assays (direct cell migration, apoptosis/necrosis, ELISA studies).
Administration of untreated eEOCs did not protect mice from AKI. Injection LY2157299 chemical structure of eEOCs treated with CF (1 mm) or FF 50 mu m did not result in any protection from ischemia-induced renal dysfunction. In vitro analysis showed reduced cellular secretion of vasoprotective vascular endothelial growth factor (VEGF), an effect that was more pronounced with CF; FF increased percentages of apoptotic/necrotic eEOCs, and both substances failed to stimulate migration of cultured cells. With lower FF concentrations (1, 5, 10 mu m) Daporinad cell survival was increased and 10 mu m FF stimulated VEGF secretion. In vivo administration of FF-treated eEOCs (10 mu m) also did not result in any renoprotective effect.
PPAR-alpha activation using fibrates does not stimulate renoprotective effects of syngeneic
murine eEOCs in ischemic AKI, although lower fibrate concentrations significantly activate eEOCs in vitro.”
“The electrical behavior of copper oxide (CuO) ceramics sintered at 920 degrees C has been characterized by a combination of fixed, radio frequency (rf) capacitance measurements, and impedance spectroscopy (IS). Fixed rf capacitance measurements on ceramics with sputtered Au electrodes revealed a temperature- and frequency-dependent high effective permittivity of similar to 10(4) in the temperature range of 150-320 K. The response is similar to that observed for relaxor-ferroelectrics, however, the magnitude of the effect can be suppressed by thermal annealing of the ceramics with Au electrodes in air at 300 degrees C or by changing the work function of the electrode material by using In-Ga as opposed to Au.
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