Aim: To investigate the correlation of HBV and fatty liver in the different demographics of age and BMI. Methods: We enrolled consecutive subjects who had received health HM781-36B cost check-up services at the Taipei Veterans General Hospital
from 2002 to 2009 and ultrasonography was used to diagnose fatty liver according to the practice guidelines of the American Gastroenterological Association. Results: Among the 33, 439 subjects enrolled in this study, fatty liver was diagnosed in 43.9% of the population and 38.9% of patients with chronic HBV infection. Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI> 22.4 kg/m2 and age>50 years. On the contrary, HBV infection was positively correlated with the presence of elevated serum ALT levels in subjects Linsitinib with fatty
liver disease regardless of their age and BMI. Conclusions: Metabolic factors are important determinants for the prevalence of fatty liver. Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients. Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease. Age distribution of fatty 上海皓元 liver stratified by HBV status. Disclosures: The following people have nothing to disclose: Chien-Wei Su, Yuan-Jen Wang, Jaw-Ching Wu, Teh-la Huo, Yi-Hsiang Huang, Han-Chieh Lin, Fa-Yauh Lee, ShouDong Lee Background and aim: To
test the association of carotid atherosclerosis with gene variants influencing hepatic fat accumulation and the severity of liver damage in patients with NAFLD. Methods: We assessed anthropometric, metabolic and histological data(Kleiner score) in 162 consecutive, biopsy-proven Sicilian NAFLD patients. Intima-media thickness(IMT), IMT thickening(IMT>1 mm) and carotid plaques(focal thickening of >1.3mm at the level of common carotid artery) were evaluated using ultrasonography. IL28B rs12979860 C>T, PNPLA3 rs738409 C>G, GCKR rs780094 C>T, LYPLAL1 rs12137855 C>T, and NCAN rs2228603 C>T single nucleotide polymorphisms were also assessed. The results were validated in a cohort of 267 subjects with clinical or histological diagnosis of NAFLD from Northern Italy, 63 of whom had follow-up examinations. Results: Carotid plaques, IMT thickening and mean maximum IMT were similar in the two cohorts, whereas the prevalence of diabetes, obesity, NASH, and PNPLA3 GG polymorphism(21 %vs.1 3%, p=0.02) were significantly higher in the Sicilian cohort.
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