Aspirin A meta-analysis [11] of ten orthopaedic trauma trials found that aspirin significantly buy Geneticin reduced the rate of deep venous thrombosis and pulmonary embolism compared with placebo. However, this reduction was significantly less
when compared with other agents like warfarin and low-molecular-weight heparin. Hence, aspirin alone provides some although suboptimal protection against thromboembolic events after hip fracture. For patients with CP673451 coronary artery stents, non-cardiac surgery increases the risk of stent thrombosis, myocardial infarction and death especially if the patients undergo hip fracture surgery early after stent implantation. Peri-operative or post-operative stent thrombosis is a life-threatening complication for patients with either bare-metal or drug-eluting stents. It is generally recommended that for such patients, aspirin must be continued throughout the peri-operative period [12] as it does not appear to increase the risk of significant bleeding after hip fracture surgery. Thienopyridines Thienopyridines (e.g., clopidogrel and ticlopidine) are often used in combination with aspirin. Dual anti-platelet therapy is especially important in patients who have
Peptide 17 concentration undergone coronary stent implantation. For patients with history of coronary stenting who present with hip fracture, it is important to know the date of the last percutaneous coronary intervention and the type of stent put in. There are limited data regarding the management of patients on dual anti-platelet agents with a recently placed coronary stent who require a semi-urgent hip fracture surgery. Discontinuation of anti-platelet therapy in these patients confers significant morbidity and mortality [13–16] because stent endothelialisation may not be complete at the time of surgery and combined with prothrombotic state induced by surgery increases the risk of acute peri-operative stent thrombosis and myocardial infarction. There is
also little evidence [12, 17] to define the true impact of continuing thienopyridine on bleeding in non-cardiac surgery. When compared with aspirin alone, the combination of clopidogrel and aspirin increases learn more the absolute risk of major bleeding by 0.4–1.0%. The American College of Cardiology and American Heart Association guidelines [18] recommend that whenever possible, elective or semi-elective procedures should be postponed until the patient has received at least the minimum length of dual anti-platelet therapy depending on whether bare-metal(BMS) or drug-eluting stent(DES) was implanted. At present, there is no definitive standard of care [19–21] on the optimum peri-operative anti-platelet regimen in patients with coronary stents particularly those with drug-eluting stents. As mentioned earlier, aspirin can be continued peri-operatively regardless of whether patient had received BMS or DES.
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