Br J Cance 1998, 77:1799–1805.CrossRef 30. Westermarck J, Kähäri VM: Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999, 13:781–792.PubMed 31. Boletta A, Qian F, Onuchic LF, Bhunia AK, Phakdeekitcharoen B, Hanaoka K, Guggino W, Monaco L, Germino GG: Polycystin-1, the gene
product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells. Mol Cell 2000, 6:1267–1273.PubMedCrossRef 32. Bhunia AK, Piontek K, Boletta A, Liu L, Qian F, Xu PN, Germino FJ, Germino GG: PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 2002, 109:157–168.PubMedCrossRef 33. Geng L, Burrow selleck compound CR, Li HP, Wilson PD: Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation. Biochim Biophys Acta 2000, 1535:21–35.PubMedCrossRef 34. Murcia NS, Sweeney WE Jr, Avner ED: New insights into the molecular pathophysiology of polycystic kidney disease. Kidney Int 1999, 55:1187–1197.PubMedCrossRef 35. Ma J, Ren Z, Ma Y, Xu L, Zhao Y, Zheng C, Fang Y, Xue T, Sun B, Xiao W: Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion
of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. J Biol Chem 2009, 284:34600–34606.PubMedCrossRef Ixazomib purchase 36. Akhurst RJ, Derynck R: TGF-beta signaling in cancer–a double-edged sword. Trends Cell Biol 2001, 11:S44-S51.PubMed 37. Merta M, Tesar V, Zima T, Jirsa M, Rysavá R, Zabka J: Cytokine
profile in autosomal dominant polycystic kidney disease. Biochem Mol PLEK2 Biol Int 1997, 41:619–624.PubMed 38. Hassane S, Leonhard WN, Van Der Wal A, Hawinkels LJ, Lantinga-van Leeuwen IS, Ten Dijke P, Breuning MH, De Heer E, Peters DJ: Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease. J Pathol 2010, 222:21–31.PubMed 39. Lu X, Kang Y: Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 2010, 16:5928–5935.PubMedCrossRef 40. Semenza GL: Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010, 29:625–634.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions All authors participated in the design, interpretation of the data and review of the manuscript. NY and WL performed the experiments and NY, WL and KT wrote the manuscript. All authors read and approved the final manuscript.”
“Background Ovarian cancer is the leading cause of death from gynecologic cancers. Every year, approximately 200,000 women are diagnosed with ovarian cancer and more than 100,000 women died of ovarian cancer around the world [1, 2].
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