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“Treatment of Alzheimer’s disease (AD) with acetylcholinesterase inhibitors (AChEI) enhances cholinergic activity and alleviates
clinical AZD8931 ic50 symptoms. In the present functional magnetic resonance imaging (fMRI) study, we investigated the effect of the AChEI rivastigmine on cognitive function and brain activation patterns during a face recognition memory task. Twenty patients with newly-diagnosed mild AD were administered a single oral dose of placebo, a single dose of rivastigmine (acute), and twice-daily treatment with rivastigmine for 4 weeks (chronic). After each treatment, MK-0518 the patients underwent a facial recognition task during fMRI. The prefrontal areas known to be involved in face recognition memory processing demonstrated greater fMRI activity in both the acute and chronic rivastigmine conditions compared to the placebo condition. In the same brain areas, differences in both fMRI activation at the map level and regional fMRI signal intensity measures between the placebo and chronic treatment conditions correlated negatively with the Mini-Mental State Examination score. In the chronic rivastigmine condition, patients with better preserved
cognitive abilities demonstrated less enhanced prefrontal activity, whereas patients with poorer cognition showed greater prefrontal activity. These findings suggest that the prefrontal attention/working memory systems are already impaired in the early stages of AD and that the effect of cholinergic medication in the brain areas involved in recognition memory, i.e., increased or decreased fMRI activation patterns, depends on the severity of the disease. These findings also suggest HM781-36B in vivo the importance of early AChEI treatment in the course of AD, at the point when there is still some cognitive reserve available and
the therapy has the highest potential efficacy.”
“Field dependence of magnetic susceptibility in nanocrystalline CoFeB film was studied in a wide frequency range from 500 kHz to 15 GHz. Anomalies of the susceptibility were detected exciting CoFeB film with a solenoidal coil, microwave strip line, in the tunable microwave cavity as well as employing magneto-optical domains imaging. Critical spin fluctuations in the form of “”soft”" modes were observed in a whole range of orientations of magnetic field perpendicular to the “”easy”" magnetic axis. A sequence of domain structure transformations was extensively examined in a “”hard”" direction in in-plane magnetic field reduced below the field of uniaxial anisotropy H(p) = 535Oe.