coli DH5α, which was suggested by the fact that E. coli DH5α by itself displayed very high resistance to such antimicrobial drugs as ethidium bromide (Table 1). Therefore, it would be more proper that the drug resistance of PsmrAB should be tested in the MDR-type transporter deficient E. coli Inhibitor Library KAM3, Based on our current data, we proposed that PsmrAB, as the homolog of YvdSR pair, should function mainly as a novel two-component Na+/H+ antiporter. We are so grateful to Dr Terry A. Krulwich (Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine of the City University, New York) for the kind gift of E. coli strain KNabc. This manuscript was supported by National
Natural Science Foundation of China (Grant No. 30960009 and 31000055), Key Project of Returned Overseas Chinese Scholars of Heilongjiang Province of China (Grant No. 1251HZ001), Special Financial Grant from China Postdoctoral Science Foundation (Grant No. 201104408), Doctor Start-up Fund of Northeast Agricultural University (Grant
No. 2009RC23) and Key Laboratory Open Fund of Soybean Biology of Ministry of Education (Grant No. SB11A05). J.J., L.W. and H.Z. contributed equally to this work. “
“Candida yeasts colonize the human oral cavity as commensals or opportunistic pathogens. They may be isolated from water circulating in dental unit waterlines mixed with traces of saliva mainly because of the dysfunction of antiretraction valves. This study deals with the growth selleck inhibitor tuclazepam ability of Candida albicans, Candida glabrata and Candida parapsilosis in tap
water with saliva (0–20% v/v). Results show that C. glabrata is the most susceptible species in tap water. Furthermore, saliva promotes both survival and proliferation of the three studied Candida species in tap water. Candida species are commonly regarded as normal constituents of the mucocutaneous microbial communities in healthy humans and are considered important opportunistic fungal pathogens (Odds, 1988; Ghannoum et al., 2010). Changes in the composition of microbiota may enhance their pathogenicity, causing superficial or systemic infections, depending on the immune status of the patient (Hube, 2004). The major source of organisms isolated from dental unit waterlines (DUWL) biofilm is the incoming mains water. Contamination of DUWL with oral microorganisms can also result from the absence or, more likely a dysfunction, of antiretraction valves that normally limit re-aspiration of fluid from the oral cavity (Bagga et al., 1984; Kumar et al., 2010). These valves require regular maintenance and replacement because they are subject to clogging due to biofilm deposition and fatigue (Williams et al., 1996). Because of such contamination, DUWL systems often deliver water to patients with microbial levels exceeding those considered safe for drinking water (Walker et al., 2000; Barben et al.
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