Estimates regarding the completeness of endoscopic resection were obtained most commonly by surgeon or observer recollection and self-report, but were also obtained through assessments of postoperative imaging studies our website and chart review in some cases. Complete endoscopic resection was defined as gross total resection of all visible tumor as confirmed by visual intraoperative assessment or by the absence of any visible tumor residual on postoperative contrast magnetic resonance imaging (MRI). Near-complete resection was defined as resection of all but a very small amount of tumor adherent to nearby tissues. Partial resection was defined by a considerable tumor remnant as assessed either intraoperatively or on postoperative contrast MRI.
Statistical analysis was performed using the Student t-test and chi-square analysis using Microsoft Excel and GraphPad Instat 3 software. If the sample size was insufficient for chi-square testing (n < 5), the Fisher exact text was used. A P value of 0.05 was considered statistically significant. 3. Results 3.1. Patients and Tumor Types The entire patient population consisted of 668 patients with intraventricular tumors who underwent attempted endoscopic resection. The publication dates of the 40 articles ranged from 1994 to 2012, and the number of patients (n) in each article ranged from 1 to 90 patients (mean, 16 patients). Hydrocephalus was seen preoperatively in 296 of 352 patients (84.1%) for whom relevant data was reported. Colloid cysts were the most frequently encountered tumor by far (n = 569, 85.
2% of study patients) followed by hypothalamic hamartomas (n = 30, 4.5% of study patients), craniopharyngiomas (n = 8, 1.2% of study patients), and ependymomas (n = 7, 1.0% of study patients). In 14 patients (2.1% of study patients) from 3 articles, the histological tumor type was either unknown or not reported. Tumor diameter ranged from 0.5 to 4.5cm in 274 tumors from series where tumor size was reported (mean diameter, 1.5cm). The most common tumor location was the third ventricle (n = 572, 85.2% of reported locations). Patient information and tumor types are summarized in Tables Tables11 and and2,2, respectively. Table 1 demonstrating articles included in the study by publication year with corresponding data regarding tumor histology, number of patients (n), presence of preoperative hydrocephalus, use of navigation/stereotactic tools, adjunctive endoscopic procedures, … Table 2 displaying the various Cilengitide tumor histologies included in the study with corresponding data regarding the number of studies included, the number of patients, resection success, complication rates, and recurrence rates for each tumor type. 3.2.
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