Initiation of therapy was 56.5 months om. No patient was lost to view. Only one patient had a local recurrence and 19 patients had distant metastases in lung, liver, both lungs and liver, Bauchh cave and lymph nodes. Among the patients with recurrence of distant metastases in 10 patients had baseline MRI stage T3 and 9 patients FTY720 Gilenia had stage T4. Figure 1 shows the start of DFS and OS for all 84 patients, the therapy. The share of the 5 and 6 year DFS was 63% and all F Ll of disease recurrence occurred within 3 years. The percentage of Grade 5 and 6 OS was 67%. Figure S2 shows the additional keeping OS and DFS for patients with stage T3 and T4 stage, based on their MRI before treatment. Recurrences occurred within 3 years in both groups.
Erg Complementary FAK pathway Figure S3 shows DFS and OS for patients with the presence or absence of malignant lymph nodes in the sample relative TME. Twenty-one patients had malignant lymph nodes in the resected specimen. For patients without malignant lymph nodes, the OS was observed for 5 years 85% versus 44% in patients with lymph node and a hazard ratio of 4.5. The 5-year DFS was 86% for patients without malignant lymph nodes versus 29% in patients with lymph and the risk-money ratio was 7.5. Figure 2 shows the OS according to TRG. TRG 4 was seen in 20 patients and TRG first M March in 56 patients. No death, local recurrence or remote TRG were observed in 4 patients. In patients with persistent disease were analyzedpredominant mode of failure. Induction CT with oxaliplatin and 5-FU in combination with radiation has been investigated.
With a median follow-up of 55 months, distant metastases were observed in 25% of patients in the ITT and a 5-year OS of 75%. The patients in our study had a median follow-up length of 56.5 months, and no patients were lost to follow-up. We found that five years is comparable with other OS CRC test, and eventually en the results of Chua et al. The controller Was Rtliche convince following the introduction of adjuvant CRT. We only had one patient with local recurrence and that person also had synchronous distant metastases. The controller The local OS does not seem to sufficiently improve the rate of recurrence and distant metastases. A high rate of PCR of 23% in the ITT group was seen. Fifty three patients had downstaging and 24 additional patients had stable disease after stage T.
Although advances in patient w Made during the treatment site, our results imply a good contr The room, and hereby support the security and the justification for the pr Surgical treatment. Of the three patients with distant metastases at the time of surgery, had the primary Rtumor downstaging and a stable disease at the local level. We found that 25% of the operated patients had distant metastases in the follow-up period. However, four patients died early and could not contribute to the follow-up observation. This should be considered when reporting the rate of distant metastases. All recurrences of the disease were observed in 3 years and DFS remained stable below. Patients who die even after 4 years, but perhaps the to other causes because we compared high median age at admission and 23 patients had an age of more than 70 at baseline and of these six patients had an age of more than 80 The data of our study was to retrospectively
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