In comparison, ultrasound (US) evaluation of the FCRt is less commonly described in the radiology literature, despite its affordability, exquisite soft tissue resolution, and the advantages of quick, dynamic diagnostic imaging. This pictorial essay describes and demonstrates the normal anatomy of the FCRt, its US examination technique and normal US appearance, and US findings of clinically relevant FCRt disorders.”
“The alkylating agent ifosfamide is an anti-neoplastic used to treat various pediatric and adult malignancies. Its potential urologic selleck products toxicities include glomerulopathy, tubulopathy and hemorrhagic cystitis. This report describes a case of proximal renal tubular dysfunction and hemorrhagic
cystitis NU7026 in a 67-year-old male given ifosfamide for epitheloid sarcoma. He was also receiving an oral hypoglycemic agent for type 2 diabetes mellitus and had a baseline glomerular filtration rate of 51.5 mL/min/1.73 m(2).
Despite mesna prophylaxis, the patient experienced dysuria and gross hematuria after a single course of ifosfamide plus adriamycin. The abrupt renal impairment and serum/urine electrolyte imbalances that ensued were consistent with Fanconi’s syndrome. However, normal renal function and electrolyte status were restored within 14 days, simply through supportive measures. A score of 8 by Naranjo adverse drug reaction probability scale indicated these complications were most likely treatment-related, although they developed without known predisposing factors. The currently Compound C purchase undefined role of diabetic nephropathy in adult ifosfamide nephrotoxicity merits future investigation.”
“Volatile oil from Palestine sweet lime (PSL) was analyzed for their chemical constituents. A total of 24 compounds were identified in hydro-distilled oil by GC-MS with electron impact mode using Zebron (ZB)-5 and ZB wax columns. The PSL volatile oil included 13 monoterpenes,
9 sesquiterpenes, one acyclic ester and one straight chain hydrocarbon. Four compounds namely d-limonene, myrcene, citronellal and beta-citronellol were further confirmed by NMR spectral analysis. In vitro treatment of PSL volatile oil exhibited dose dependent inhibition of colon cancer (SW480) cell proliferation. Induction of apoptosis by the PSL volatile oil was confirmed through Annexin V staining indicating translocation of phosphatidylserine from inner to outer leaflet of plasma membrane, upon incubation of cells with volatile oil at 50 mu g/mL. Treatment with PSL volatile oil suppressed the expression of both Cox-2 and IL-6 suggested the potential inhibition of inflammation and activation of apoptosis in human SW480 colon cancer cells. Suppression of Cox-2 and IL-6 expression in the cells treated with PSL volatile oil were significant compared to treatment with d-limonene (50 ppm), one of the major constituent of citrus volatile oils.
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