In insulinoma it has been noted that octreotide treatment may make hypoglycemia worse in those patients lacking SSTRs 2 and 5, and, as glucagon secretion is also inhibited, patients have to be observed closely at the beginning of therapy to prevent severe hypoglycemia due to the reduced glucagon-dependent counter-regulation [35]. Hence, this treatment has to be started in a hospital setting, GDC-0068 solubility dmso and should
be reserved for only the minority of insulinoma patients with positive imaging on SRS. Vezzosi et al recently assessed that octreotide was effective in the control of hypoglycaemia in more than 50% of the insulinoma patients. The treatment was effective in all SSTR 2 positive patients and in a few SSTR 2 negative ones, while no relation between treatment effectiveness and the expression of SSTR 5 was observed [36]. These results are in concordance with other case reports and smaller series of insulinoma patients reported in the literature [37–41]. In glucagonoma patients somatostatin analogue treatment Evofosfamide mw is indicated for alleviating the symptoms related to the characteristic skin rash (necrolytic migratory erythema) or diarrhoea [42–46]. In somatostatinomas symptoms are due to somatostatin hypersecretion (hyperglycaemia, cholelithiasis, diarrhoea and
steatorrhoea, hypochlorhydria) or to the mass effect [47]. Although it seems a paradox to treat patients with symptoms related to elevated SST levels with a somatostatinoma, in 1998 Angeletti et al showed that octreotide treatment was effective in reducing plasma levels of somatostatin and improving the related symptoms in three patients with metastatic somatostatinomas [48]. Recently, have been described nine cases of VIP-oma Docetaxel in which octreotide was very successful as adjuvant therapy for symptoms control and for reducing the serum elevated VIP levels improving the diarrhoea and the electrolyte imbalance [49–51]. The anti tumour effects of SST analogues The antineoplastic activity of somatostatin analogues has been
demonstrated in several experimental models in vivo and in vitro [52–57]. However, there is still little known regarding the antiproliferative role of SSA in GEP NETs, although increasing data suggest that such analogues can be tumouristatic, at least in some circumstances [58]. The antineoplastic action of SST analogues depends on the kind of tumour and the receptor subtypes they are bound to, and occurs through direct and indirect mechanisms. While direct activities are mediated by BIBW2992 datasheet specific membrane receptors and include antimytotic and apoptotic effects, indirect effects do not depend on the receptor bonging and encompass the growth factor inhibition, antiangiogenic and immuno-modulating activities. As a matter of fact, SST analogues are able to inhibit the growth of Swarn chondrosarcoma, used as experimental model of SSTR free tumour [59].
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