In the near future, it is expected that non-invasive prenatal diagnosis (genetic analysis on foetal DNA extracted from maternal blood) will be possible for a limited number of indications. The major advantage
of this type of PND is the avoidance to a large extent of the abortion risk. Research showed that the psychological impact of pregnancy termination increased as gestational age advanced (Davies et al. 2005). Overall, women experienced intense grief, trauma, psychological complaints and pressure on the partner relationship after late pregnancy termination (>16 weeks gestation) and occasionally learn more regret (Korenromp et al. 2006). While most women were able to resolve their grief, more than one third of the women still experienced elevated levels of trauma and grief up to 4 years after the pregnancy termination (Davies et al. 2005; Korenromp et al. 2005a; Hunfeld et al. 1997; Korenromp et al. 2007). Because of the impact of ending a desired pregnancy, it is important that
couples are prepared for all the issues involved in the decision whether or not to opt for PND. The severity of the condition, its treatability, the family history of the condition and the couples’ attitude towards pregnancy termination all contribute to the couple’s perception of the disease and their motivation for PND. Couples who have lost relatives SIS3 cost or witnessed the symptoms of a disease may be more motivated to prevent passing on the disease allele
and opt for PND, and may experience fewer doubts than couples who have not witnessed the disease. Couples do not always agree on whether they wish to have PND. In our clinical experience, men are more inclined to opt for PND than women. Moreover, research has shown that women and men also respond differently to pregnancy termination. Women experienced more grief and trauma from pregnancy termination than men, but women receiving partner support generally coped better (Korenromp et al. 2005b; Geerinck-Vercammen and Kanhai 2003). For the quality of the partner relationship, it is important that couples resolve http://www.selleck.co.jp/products/DAPT-GSI-IX.html their differences and decide about PND in unison. Preimplantation genetic diagnosis In our experience, couples generally perceive PGD as an CBL-0137 purchase option when ending a pregnancy is not an option or when they already need IVF due to decreased fertility. In the Netherlands, there is a committee reviewing PGD requests. As a guideline, each condition that is an indication for PND is also an indication for preimplantation genetic diagnosis (PGD); however, there are exceptions (Geraedts and De Wert 2009). PGD involves in vitro fertilization, testing the embryo genetically and transferring it to the uterus only if it is not carrying the disease allele (van Rijn et al. 2011). PGD requires considerable time and effort, with a pregnancy rate of around 15–20 % each trial (http://www.pgdnederland.nl/).
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