Information about each patient’s smoking status, including amount used, starting and stopping dates, and changes in use over time were obtained. The dose-response relationships between cigarette smoking and the outcomes were assessed by using multivariate Cox proportional hazards models selleck adjusted for clinically relevant factors. The primary and secondary outcomes were a 50% increase over the baseline serum creatinine level and first complete remission (CR) of proteinuria, respectively. Results: Throughout the observation period (median, 37 months;
interquartile range, 16–71 months), 22 (12.9%) patients developed a 50% increase in the serum creatinine level and 2 (1.2%) progressed to ESRD. CR was achieved by 103 (60.2%) patients. Multivariate Cox proportional hazards models indicated that current smoking was associated with a 50% increase over the baseline serum creatinine level (adjusted hazard ratio [HR], 6.59 [95% confidence interval (CI), 2.13–21.6]) and female sex (adjusted HR, 3.17 [95% CI, Selleckchem Imatinib 1.02–9.80]). The number of cigarettes smoked daily (adjusted HR, 1.62 [95% CI, 1.16–2.27] per 10 cigarettes daily) and cumulative smoking of ≥40 pack-years (adjusted HR, 5.71 [95% CI, 1.80–19.1]) were significant predictors of the primary outcome. However, smoking was not associated with CR. Conclusion: Smoking is a significant and dose-dependent risk factor for IMN progression.
All patients with IMN who smoke should be encouraged to quit. ISMAL KIRANMAI1,4, SAHAY MANISHA2, VALI SHARMAS3, GOWRI SHANKER SWARNALATHA4 1Osmania General Hospital; 2Osmania General Hospital; 3Osmania General Hospital; 4Apollo Hospital Introduction: Malignancy can produce variety of Renal lesions in kidney. Our Aim is to study the prevalence and spectrum Molecular motor of Renal lesions among patients with malignancy who underwent Renal Biopsy. Methods: We
retrospectively analyzed the Data of 100 patients of Malignancy in whom the Renal biopsy was performed.Indications for Biopsy were: Renal failure and Nephrotic syndrome in patients with malignancy. Renal biopsies were processed by standard methods examined under light, fluorescent, Microscopy and EM wherever required. All biopsies are reported by a single histopathologist. Results: There were 100 patients. Ratio of Male and Female was 7:3. 82 were Multiple Myeloma. 14 females/ 68 males. Mean age 59 +/− 11 years. Cases presented as RPRF/ Nephrotic Syndrome with Renal insufficiency and Nephrotic Syndrome. The histological spectrum of Renal lesions were: Cast nephropathy 40% (32), Amyloidosis- 34% (27), LCDD-10% (8), AIN-7.5% (6), ATN-2.5% (2), MCD-1.25% (1), MPGN-5% (4). 9 cases of Lympho Proliferative disease have presented as ATIN(4) 44%, diffuse infiltration of the kidney by lymphoblasts. (3) 33% Amyloidosis (1) 11%, SLE Class IV (1) 11%.
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