G / ml 4 methylcatechol suggesting that cytochrome C may need during the treatment was dismissed. We also observed dose- Independent erh Increase of the cleaved form of caspase 3 and ITMN-191 Danoprevir caspase 9 after treatment, indicating the involvement of activation of the caspase cascade. Although the H He does not act the entire 4-methylcatechol, the H Height of the active form of Akt was found to decrease suggesting that the compound has the activity t of Akt-mediated survival of the cell inhibits change. Together all the results by Western blot, suggesting that 4 methylcatechol induces apoptosis by disrupting the survival and apoptosis equilibrium with metastatic melanoma cells and that apoptosis mediated by the mitochondrial generation of reactive oxygen species.
Discussion Although the recovery rate of localized cutaneous melanoma concerning Gt 90%, decreases as the survival of melanoma spreads locally and in patients with disease that has spread to distant organs low. The use of currently available therapeutic agents of the spread of the disease is partly due to the high toxicity t due to the low response rates and survival benefit is limited. With the lack of standard of care that all melanoma patients will benefit, it is unerl Ugly to attend to patients with advanced melanoma in clinical trials. A handful of drugs including normal medicines and vaccines are in various stages of clinical trials. It is expected that only a fraction, if this test can be successfully developed agent for the therapy of melanoma.
Furthermore, the fact remains that all patients with advanced melanoma benefit from the small number of agents being developed for clinical use can k,. Moreover, notorious for melanoma develop resistance to therapy. because it takes 7 to 15 years to the development of therapeutics, the development of a pipeline from laboratory tests on potential drug candidates based on actively pursued. In this effort, we report on the biological effects of 4 methylcatechol on malignant melanoma cells. 4 methylcatechol is a known metabolite of quercetin flavonoids Of which are found naturally in fruits and vegetables. It will inhibit the digestive tract after consumption of quercetin and it was shown that lipid peroxidation and cholesterol biosynthesis in rat hepatocytes. There are many reports about the F Ability of the parent compound, quercetin benefits for human health, including normal and cancer prevention of cardiovascular diseases.
It was suggested that polyphenolic compounds have antioxidant effects of parental guardian and thus inhibit tumorigenesis. In addition, these parent compounds inhibit the growth of a variety of cancer cells, including normal Leuk Chemistry and non-small cell lung cancer. Quercetin protected colorectal adenoma cells from fat Acid hydroperoxide-induced oxidative stress, but increased in colorectal tumor cells quercetin Hten oxidative stress and apoptosis in about 40 to 60% of the cells induced. In osteoblasts, quercetin has been found that caspase-dependent To induce apoptosis Independent. Quercetin was found to tumorigenesis, invasion and inhibit apoptosis in a variety of melanoma cells in culture and xenograft models. Quercetin has been found metabolism of F Selectively sensitize melanoma cells that express tyrosinase increased to Hen
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