Is used 
, breast, stomach and pancreatic cancer. It also has utility as a topical treatment of superficially Chlichen basal cell carcinoma that can not be treated with surgery MDV3100 and actinic keratosis, a pr Kanzer Sen skin condition. Much work has been done since the approval of this drug, our amplifier Ndnis improve the mechanism of action, and this work has been widely reviewed.20, 21 As shown in Figure 6 Fura metabolism is very complex. Fura is UMP by F orotate phosphoribosyl transferase, which converted the first stage of activation. Nucleotide kinase F UMP then to F, UTP, one of the most important intracellular Ren metabolites of fura is to convert. Used included F UTP as substrate for the synthesis of RNA instead of uridine triphosphate, and a betr Chtliche amount of Fura in all RNA species.
The incorporation of Fura in various RNA species has been shown that Ren the function of these RNA species to st, But these effects observed at high concentrations. There are XL147 different types of RNA molecules, and the effect of Fura many of the newest features of the RNA has not yet been rated. It is assumed not to contribute to the installation of Fura into RNA not its cytotoxic activity of t, but because of the complexity of t RNA, RNA-directed action pr Cise was defined. It is likely that the incorporation into RNA longer contribute to a failure and that the inhibition of RNA many activity Th to their activity Th directed RNA. Although the incorporation into RNA is an important mechanism of action of fura actions directed RNA are considered secondary R to the Ma Took directed DNA described which Similar to the case with thiopurines.
F UDP is a substrate for ribonucleotide reductase, which removes the 2 OH group. DUDP F is a good substrate for nucleoside diphosphate kinase F dUTP form which is an excellent substrate for DNA polymerases. F dUTP by DNA polymerases for DNA synthesis used as efficiently as the thymidine triphosphate. Therefore, if dUTP F accumulated in cells, it will be incorporated into DNA by DNA polymerases. Human cells have a mechanism be developed to Recogn Uracil in DNA and remove, since a betr Chtliche amount of uracil in the DNA of the cell by spontaneous deamination of cytosine and uracil formed from base pairs like thymine, cytosine deamination of DNA, which ones registered with a simultaneous mutation.
The enzyme responsible for the removal of uracil DNA glycosylase uracil and Recogn t Fura into DNA as a substrate and removes it from DNA, which then causes only one side apyrimidinic, recognized by the apurinic / apyrimidinic endonuclease 1, resulting in a single strand break. Inflow Ngiges pause is detected by DNA repair enzymes, and in Similar way as defined TG resynthesis and repair of DNA, forming a futile cycle, which then causes no inhibition of DNA synthesis and cell death. Another mechanism, the cell used is to obtain the uracil-DNA to prevent the use as a substrate by DNA polymerases. Since human cells contain the necessary enzymes, dUTP, human cells also express the dUTPase dUTP dumping converts and h LT A very low level of dUTP in the cell. dUMP is a substrate for thymidylate synthase and is used for the synthesis of thymidine nucleotides. dUTPase also recognized
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