Patients with a history of diabetes mellitus or cardiovascular disease of psoriasis were likely to be treatment resistant.”
“Two new norditerpenoid alkaloids, named
scutebarbatines M-N (1 and 2), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were established on the basis of detailed spectral analyses. In vitro, two new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma and HT29 colorectal carcinoma cells), and gave IC50 values in the range of 3.5-6.3 mu M.”
“There are a limited number of reports indicating the role of human leukocyte antigen Screening high throughput screening (HLA) class I alleles in pemphigus C59 wnt vulgaris. This study was designed to highlight the association of HLA class I alleles with pemphigus vulgaris in Iran. Fifty patients with pemphigus vulgaris, diagnosed
based on clinical, histological and direct immunofluorescence findings were enrolled into this study. The control group consisted of 50 healthy, age- and sex-matched individuals. HLA typing of class I (A, B and C alleles) was carried out using polymerase chain reaction based on the sequence-specific primer method. This study showed the higher frequency of HLA-B*44:02 (P=0.007), -C*04:01 (P<0.001), -C*15:02 (P<0.001) and -C*16:01 (P=0.027) in the patient group, compared to the controls, while the frequency of HLA-C*06:02 (P<0.001) and -C*18:01 (P=0.008) in the patients with pemphigus vulgaris was significantly lower than the controls. Regarding the linkage disequilibrium between HLA class I alleles, the HLA-A*03:01, -B*51:01, -C*16:02 haplotype (4% vs 0%, P=0.04) is suggested to be a predisposing factor, whereas HLA-A*26:01, -B*38, -C*12:03 haplotype (0% vs 6%, P=0.01) is suggested to be a protective factor. In conclusion, it is suggested that HLA-B*44:02, Batimastat in vivo -C*04:01, -C*15:02 alleles and HLA-A*03:01, -B*51:01, -C*16:02 haplotype are susceptibility factors for development of pemphigus vulgaris in the Iranian population, while HLA-C*06:02,
-C*18:01 alleles and HLA-A*26:01, -B*38, -C*12:03 haplotype may be considered as protective alleles.”
“The antioxidant properties of the water and ethanol leaf extracts of kinkeliba (Combretum micranthum) were investigated, including scavenging of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (IC50 values: 8.02 +/- 0.34 for the ethanol extract [KE] and 9.1 +/- 0.28 for the water extract [KW]), the 2,2′-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical (IC50 values: 7.4 perpendicular to 0.14 for KE and 11.8 perpendicular to 0.01 for KW) and the hydroxyl radical (58.1% for KE and 61.1% for KW). The ferric thiocyanate method, reducing power, metal chelating activity, an assay of protein oxidation and the beta-carotene-linoleic bleaching assay were also used. Butylated hydroxytoluene and ascorbic acid were used as the reference antioxidant compounds.
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