\n\nPrimary variables of interest. Demographic and clinical diagnosis data on ICU admission, APACHE II, days of mechanical
ventilation, days of renal replacement therapy (RRT) and the mortality were collected.\n\nResults. During the study period, 3786 patients were admitted to the ICU, 66.7% male and 2469 (65.2%) < 65 years. Mortality in the ICU of the coronary group was greater in women (11.1% vs 6.7%; p = 0.02), even though there were no significant differences between both genders in the APACHE II (p = 0.56). No statistically significant differences were found according to gender in age (< or >= 65 years), in the APACHE II, or in the need for mechanical ventilation or renal replacement therapy as well as in the ICU mortality. We also found no differences in the mortality between the diagnostic groups and gender even when the APACHE II was β-Nicotinamide chemical structure significantly Temsirolimus greater on admission, as occurred for the women < 65 years of the coronary and traumas
group and for women with surgery >= 65 years.\n\nConclusions. No significant differences were demonstrated in the outcome in relationship with gender except for in the coronary group in which mortality was greater in women. Age above or below 65 years had no influence on mortality in our patients.”
“Deep Lake in Antarctica is a cold, hypersaline system where four types of haloarchaea representing distinct genera comprise bigger than 70% of the lake community: strain tADL similar to 44%, strain DL31 similar to 18%, Halorubrum lacusprofundi similar to 10% and strain DL1 similar to 0.3%. By performing comparative genomics, growth substrate assays, and analyses of distribution by lake depth, size partitioning and lake nutrient composition, we were able to infer important metabolic traits and ecophysiological characteristics of the four Antarctic haloarchaea
that contribute to their hierarchical persistence and coexistence in Deep Lake. tADL is characterized by a capacity for motility via flagella (archaella) MLN2238 research buy and gas vesicles, a highly saccharolytic metabolism, a preference for glycerol, and photoheterotrophic growth. In contrast, DL31 has a metabolism specialized in processing proteins and peptides, and appears to prefer an association with particulate organic matter, while lacking the genomic potential for motility. H. lacusprofundi is the least specialized, displaying a genomic potential for the utilization of diverse organic substrates. The least abundant species, DL1, is characterized by a preference for catabolism of amino acids, and is the only one species that lacks genes needed for glycerol degradation. Despite the four haloarchaea being distributed throughout the water column, our analyses describe a range of distinctive features, including preferences for substrates that are indicative of ecological niche partitioning.
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