Regions included New England (NE), Mid-Atlantic (MA), East North Central (ENC), West North Central (WNC), South Atlantic (SA), East South Central (ESC), West South Central (WSC), Mountain (M), and Pacific (P). Results: A total of 2,974 specimens were submitted from 44 states representing all 9 U.S. geographic regions. Median age was 44 years (range, 0.02 to 91) with 59.3% of specimens from males. Despite a significant selleckchem decline in assay success between 2007 and 2012 (81.0% vs. 59.7%, P <0.0001), 1,933 of 2,974 (65.0%) specimens yielded HBV sequences: GT A (37.0%), B (19.2%), C (21.2%), D (12.5%), E (5.1%), F (1.1%), G (2.9%), and H (0.6%), with 7 unresolved sequences (0.4%). GT G (n=56) occurred in males with greater
frequency than GT A, B, C, D, E, F, or H (P <0.01). GT A occurred in males with greater frequency than GT B or GT C (P <0.0001) and occurred more frequently in NE than in ENC, WNC, SA, ESC, or WSC (P <0.015). GT C occurred more frequently in P than in NE,
MA, ENC, WNC, SA or WSC (P <0.05). While no DR was identified in 90.1% of HBV sequences, rates GDC-0068 chemical structure of DR to 1, 2, and 3 drugs were 2.2%, 6.9%, and 0.8%, respectively. Resistance to 3TC and LdT was more frequent in WSC than in NE, ENC, WNC, or SA (P <0.003), while resistance to ETV, 3TC, and LdT was more frequent in P than ENC (P <0.03). Conclusion: Significant differences in HBV GT and DR exist within a large cohort medchemexpress of clinical specimens of U.S. origin and submitted to a national
reference testing laboratory for HBV GT and DR testing. Regional differences may reflect differences in population demographics not considered in these analyses. Disclosures: Joseph D. Yao – Consulting: Abbott Molecular, Inc., Roche Diagnostics Corp.; Grant/Research Support: Abbott Molecular, Inc., Roche Diagnostics Corp. The following people have nothing to disclose: Jeffrey J. Germer, Yuna Choi, Jayawant N. Mandrekar Objective: To compare the viral load decay kinetics of mutant vs. wild-type (WT) virus in chronic hepatitis B infected patients harboring rtM204V and/or rtM204I prior to treatment with TDF or FTC/TDF therapy. Methods: Baseline samples were quantified for rtM204V/I subpopulations from all patients (n=280) in Study GS-US-174-0121, a study that evaluated TDF vs. FTC/TDF in patients harboring LAM-R at screening. Allele-specific PCR assays (AS-PCR) were designed to detect rtM204V or rtM204I mutant and rtM204M WT populations in serum samples with HBV DNA ≥1000 copies/mL, with an assay sensitivity of 0.5% of the total population. Seventeen patients (TDF, n=8; FTC/TDF, n=9) with a mixture of WT and rtM204V/I populations at baseline were evaluated for the percentage of rtM204V/I subpopulations at all study visits until HBV DNA was <1,000 copies/mL. Differences in HBV DNA decline rates and the percentage of rtM204V/I subpopulations on treatment were evaluated using the Wilcoxon Rank Sum and signed rank tests.
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