Remarkably, lack of Nrf2 let to markedly higher magnitudes of the

Remarkably, lack of Nrf2 let to markedly higher magnitudes of the increases AZD6244 in hepatic CD133 protein level and in the number of CD133+ hepatocytic-appearing cells. Conclusion: Collectively, our data demonstrate that Nrf2 deficiency evokes higher activity of liver progenitor cells and thus stronger liver

repair response. Key Word(s): 1. Cholestasis; 2. Nrf2; 3. liver regeneration; Presenting Author: LUOJIAN WU Additional Authors: TANGGUO DU Corresponding Author: TANGGUO DU Affiliations: guangxi medical university Objective: To discuss the optimal time of application enhanced CT in acute pancreatitis and the importace of CT severity index in evaluating the severity of acute pancreatitis. Methods: Thescores of 181 cases of AP evaluated by CTSI scoring systemswere retrospectively analyzed. To compared the relationship between CTSI and duration of hospitalization, pleural effusion and organ failure. Results: CTSI scores the severity into three levels, Level I: 0–3; rated its severity II class: 4 to 6:

IlI: 7 to 10 points. >7 considered as acute Dactolisib pancreatitis, level IlI was analyzed with 40 patients, enhanced CT in 4–5 day showed the importance in early detection of the severity of the disease. The CTSI score has correlation with hospitalization time, pleural effusions and organ failure. Conclusion: Applying enhanced CT in 4–5 days is the best time for the acute pancreatitis patients, can diagnose the severity of acute pancreatitis. The higher CTSI score, the longer hospital stay, higher incidence of pleural effusion, and organ failure, the worse the prognosis. Key Word(s): 1. Acute pancreatitis; 2. Enhanced CT scan; 3. CT severity Index; 4. pleural effusion; Presenting Author: LIN WU Additional Authors: JUN GAO, FANGYU WANG, ZHAOSHEN LI Corresponding Author: FANGYU WANG Affiliations: Department of Gastroenterology and Hepatology Jinling Hospital; Changhai Hospital of Second Military Medical University; Department of Gastroenterology and Hepatology Jinling

Amisulpride Hospital, Nanjing University School of Medicine; Changhai Hospital, The Second Military Medical University Objective: Intestinal barrier failure plays a critical role in systemic inflammation and pancreatic infection in severe acute pancreatitis (SAP). Treatment with glucocorticoid extenuates intestinal barrier failure in SAP animal models, but the mechanism remains unclear. The present study aims to investigate the effects of methylprednisolone on the intestinal barrier function and its potential mechanisms in a SAP rat model. Methods: Male SD rats (250–350 g) were randomized into 5 groups: Sham operation group (n = 8), Severe acute pancreatitis group (SAP, n = 40), and SAP rats intramuscularly injected with methylprednisolone (MePr, 15 mg/Kg or 30 mg/kg; n = 10 for each group) or with Sodium Chloride (NS; n = 20).

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