Severity of histological damage was graded according to the stren

Severity of histological damage was graded according to the strength of inflammatory Selleckchem PD0325901 cell infiltration and liver cellular necrosis. TNF-α and INF-γ levels in supernatant fluid released from

lymphocytes of the spleens were also measured. Results: Results: The EAIHs induced by peak II protein plus CFA and S100 plus CFA had significantly higher histological grades (2.8 and 2.6 on average) than those induced by peak I proteins plus CFA and peak III proteins plus CFA or by CFA alone and saline alone (2.2, 1.6, 1.0 and 0.2 respectively) (p < 0.05). T-cell reactivity increased after the stimulation with hapten peak I protein as compared with those of other groups. TNF-α and INF-γ levels in supernatant fluid from the lymphocytes of the spleens were increased significantly with the development of EAIH (p < 0.05). Conclusion: Conclusion:

Syngeneic hapten protein S100, and its three this website separated peak proteins had different immunopathological potentials on the pathogenesis of EAIH with peak II protein being more liver-specific than the others. Key Word(s): 1. liver; 2. antoimmune; 3. autoantigen; Presenting Author: WEIMIN XU Corresponding Author: WEIMIN XU Affiliations: Gastroenteroiogy Objective: To investigate the clinical value of detection of autoantibodies in 103 patients with elevated liver enzymes. Methods: three group patients (103 patients with elevated liver enzymes,85 patients with chronic hepatitis B, 80 healthy subjects) were examined for autoantibodies respectively. Antinuclear antibody (ANA), antimitochondrial antibody (AMA) and anti-smooth muscle antibody (SMA) were tested by indrect immunofluorescence; Antibodies to soluble liver antigen/liver

pancreas (SLA/LP), liver kidney microsomal type 1(LKM-1), liver cytosol type 1(LC-1) and mitochondrial type II (AMA-M2) were tested by Western blot. Results: Among 103 patients with elevated liver enzymes, LKM-1 was positive in 2 patients and SLA/LP in 1 patient and AMA-M2 in 3 patients. The positive rates of ANA, AMA, SMA in chronic hepatitis B group were 12.9%, 1.1%, 2.3% respectively; that in patients with elevated liver enzymes group were 34.9%, 8.7%, 12.6% respectively; that selleck chemicals llc in control group were 5.0%, 0, 0 respectively. The positive rates of ANA, AMA, SMA in chronic hepatitis B group and in patients with elevated liver enzymes group were significantly increased as compared with those of control group (p < 0.05). 6 patients with primary biliary cirrhosis (PBC) and 4 patients with autoimmune hepatitis (AIH) were diagnosed in 103 patients with elevated liver enzymes. Conclusion: The autoantibodies detection in patients with elevated liver enzymes has an important significance in clinical diagnosis.

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