The autoimmune disease alopecia areata causes harm to hair follicles, and follicular melanocytes may be a part of the autoimmune process. Similarly to vitiligo's presentation, there could be a connection between sensorineural hearing loss and alopecia areata. Potential auditory difficulties in individuals with alopecia areata were the focus of this investigation. This cross-sectional investigation included 42 subjects diagnosed with alopecia areata and an equal number of healthy individuals. Patients and control subjects underwent hearing evaluations utilizing vestibular evoked myogenic potentials, otoacoustic emissions, and pure-tone audiometry. A normal otoacoustic emission was observed in 59.5% of subjects with alopecia areata, compared to 100% of control subjects (P = 0.002). Subjects with alopecia areata demonstrated significantly higher speech recognition thresholds (p = 0.002) and speech discrimination scores compared to control subjects (p = 0.005). A lack of vestibular evoked myogenic potential response was observed in 6 (143%) of the patients with unilateral involvement and 2 (48%) of those with bilateral involvement within the alopecia areata group. No significant difference was observed in the vestibular evoked myogenic potential (VEMP) amplitudes between the patient and control groups (P = 0.097). Our investigation's scope was constrained by the limited sample size and the qualitative nature of the otoacoustic emission measurements. Hearing loss was determined to be more common in alopecia areata patients relative to the healthy individuals included in the study. The inflammatory response in alopecia areata might include follicular melanocytes, whose destruction could affect inner ear hearing. Although alopecia areata's duration and severity were examined, there was no substantial correlation with hearing loss levels.
Of all the tissue and cellular grafting techniques employed for vitiligo treatment, melanocyte transfer through ultrathin skin grafting (UTSG) offers rapid re-pigmentation. Psoralen and ultraviolet A radiation, obtainable through natural sunlight or narrowband ultraviolet light B or with an excimer laser/lamp (308 nm), is utilized to further expedite the regimentation process. Our study investigated the efficacy of carbon dioxide laser ablation, coupled with melanocyte transplant/transfer via ultrathin skin grafts, subsequently treated with excimer lamp therapy, in patients with stable vitiligo. Patients with stable vitiligo, totaling one hundred ninety-two, received UTSG treatment after carbon dioxide laser ablation and were then placed on excimer lamp therapy. The primary efficacy outcome was determined at the end of a one-year timeframe by assessing the degree of regimentation and the level of color accuracy. The study enrolled 192 stable vitiligo patients, with a mean age of 32 years and 71 days. Among the 410 lesions examined, an exceptional 394 lesions showcased excellent regimentation, registering a success rate of 961% at the one-year mark. However, 16 lesions (accounting for 39%) situated on the fingertips and toe tips exhibited poor or no regimentation at both the 3-month and 1-year follow-up stages. In the domain of color matching, 394 (961%) lesions achieved a superb color match at the one-year follow-up, but 16 lesions (39%) did not achieve adequate or any color match. This single-center study, unfortunately, had a small sample size. When melanocyte transfer/transplant is performed using ultra-thin skin graft sheets, following carbon dioxide laser ablation and in conjunction with excimer lamp therapy, favorable cosmetic outcomes are achieved with a swift restoration of regimentation in stable vitiligo.
Various aspects of journal performance, including impact, output, and prestige, are measured through bibliometric techniques, which utilize citation-based metrics derived from background documents. The objective of this research was to gather bibliometric data from Indian dermatology and other Indian academic journals, to assess their comparative strengths. medieval London We examined journal metrics for Indian publications, particularly in dermatology (IJDVL, IJD, Indian Dermatology Online Journal, Indian Journal of Pediatric Dermatology, International Journal of Trichology) and additional subject areas (IJMR, IJP, Indian Journal of Ophthalmology, Indian Journal of Pharmacology). Data for the eight metrics—Journal Impact factor, SCImago Journal Rank, h5-index, Eigenfactor score, normalized Eigenfactor Score, Journal Citation Indicator, Scimago Journal and Country Rank H-index, CiteScore and Source Normalized Impact per Paper—was gathered in the year 2021. In 2021, among Indian dermatology journals, IJDVL exhibited the most significant impact factor (2.217) and a substantial h-index of 48. Prestige metrics, including SCImago Journal Rank (0403), Eigenfactor score (000231), and Source Normalized Impact per Paper (1132), placed IJD at the forefront. Relative to the average dermatology journal, IJDVL demonstrated a deficiency in all three prestige metrics. Two journals, IJMR and IJP, from other disciplines included in the selection, achieved impact factors exceeding five, a significant improvement compared to their position two years prior, which was behind IJDVL. The normalized scores for most entries registered values greater than 1, representing superior performance in comparison with the typical journals of their respective disciplines. Omitting altmetrics information, the conclusion is that IJDVL emerges as a leading Indian dermatology journal, closely matching IJD in prominence. Evidently, IJDVL's influence has grown significantly over the past ten years, as indicated by multiple performance indicators. Nevertheless, the advancement of this journal lags behind the global dermatology journal average, as demonstrated by the field-adjusted journal metrics, suggesting future potential for increased impact.
Sturge-Weber syndrome (SWS) involves a GNAQ gene mutation, a rare occurrence that affects the development of neural crest cells. For SWS, a pulsed dye laser (PDL) is a first-line treatment option; however, its results are less satisfactory than those seen in port-wine stain (PWS) patients. In the realm of PWS treatment, photodynamic therapy emerges as a promising therapeutic strategy. Yet, the use of PWS in relation to SWS has not been a frequent subject of research. The research focuses on investigating the positive and negative impacts of photodynamic therapy in the treatment of PWS, a condition connected to SWS. Patients with SWS, alongside matched patients presenting with extensive facial PWS, formed the basis of this study. To evaluate patient reactions to treatment, colorimetric and visual assessments were performed. Visual and colorimetric analyses (blanching rate and color improvement scores) demonstrated comparable treatment responses in the SWS and PWS groups following two PDT treatments. These responses were numerically similar (212% vs. 298%; 339 vs. 365), and statistically significant (P = 0.018, P = 0.037). genetic prediction A substantial disparity in efficacy was observed between patients with SWS who had, and who had not, received prior treatment, resulting in 124% and 349% improvement, respectively (P = 0.002). Furthermore, the location of the lesions on the central and lateral facial regions displayed different effects on efficacy (185% and 368% improvement, respectively; P = 0.001). Both the SWS and PWS study groups encountered minor adverse events, and the rate of these events was comparable across the two cohorts. A critical limitation of the research was the small sample studied and the potential for glaucoma to present itself at a later point in time. Additionally, the young age of some participants complicated the assessment of MRI results for SWS, preventing the exclusion of false-negative readings. A safe and effective therapeutic recourse for SWS-accompanied PWS is photodynamic therapy. Individuals possessing no prior treatment history and presenting with lesions situated on the lateral aspects of their faces demonstrated a favorable response, showcasing compelling efficacy.
A common characteristic of pachyonychia congenita is plantar keratoderma, which causes substantial impairment in ambulation and a marked reduction in quality of life. Pain reporting methodologies in pachyonychia congenita studies are heterogeneous, making it difficult to assess the efficacy of treatment outcomes for painful plantar keratodermas. We aim to objectively examine the relationship between plantar pain and activity levels within a population of pachyonychia congenita patients, using a wristband tracker for measurement. Patients with Pachyonychia congenita and corresponding control subjects, using wristband activity trackers and daily digital surveys, recorded daily pain levels (0-10 scale) comprising both the highest and total pain scores for 28 consecutive days during the four seasons. Twenty-four individuals, specifically twelve with pachyonychia congenita and twelve matched healthy controls, completed the study in its entirety. Pachyonychia congenita patients experienced a reduction of 180,130 steps per day (95% confidence interval, -36,664 to 641) compared to normal controls (P = 0.0072), while also reporting significantly higher average (mean 526, standard deviation 210) and maximum (692, standard deviation 235) daily pain levels compared to the normal control group (mean 0.11, standard deviation 0.047, and 0.30, standard deviation 0.022 respectively) (P < 0.0001, for both comparisons). A statistically significant association (P = 0.0066) exists between a one-unit increase in the maximum daily pain level and a corresponding average reduction in pachyonychia congenita activity by 7154 steps per day; the standard error is 3890 steps. CVN293 nmr The study's statistical power was compromised by the limited number of participants involved. Individuals diagnosed with pachyonychia congenita, aged 18 or more, and carrying mutations in keratin 6a, keratin 16, and keratin 17, were the sole participants; this restricts the broader applicability of the research.
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