The FRET signals from multiple chambers are simultaneously monitored under a fluorescent microscope for long-time observation and the on-chip results are compared with those from 96-well plate study and the methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. The microfluidic platform shows several advantages including high-throughput capacity, low drug consumption, and high sensitivity. (C) 2010 American Institute of Physics. [doi:10.1063/1.3398319]“
“Objective: Chromosome 22q11 microdeletion syndrome (del22q11) is the most frequent microdeletion syndrome in humans, with an estimated incidence of 1/4000. It is recognized as a common identifiable cause
of cleft palate. We characterized palatal abnormalities in a large cohort of Chilean patients with del22q11.
Methods: Patients with the deletion were evaluated by geneticists Sapanisertib mw and
speech pathologists, including nasopharyngoscopy when indicated. SNDX-275 Comparisons between groups with and without palatal abnormalities were performed using Fisher’s exact test and Mann-Whitney U test.
Results: Two hundred and one patients were included in the study. Palate abnormalities were present in 154 patients (76.6%). The most frequent finding was submucous cleft palate (both classic and occult forms) seen in 80 patients (39.8% of the total group). Overt cleft palate or cleft lip/palate was seen in 30 patients (14.9%). Patients without palate abnormalities had significantly greater frequency of congenital heart disease and higher mortality.
Conclusions: Our data show a high frequency of palate abnormalities without significant association with congenital heart disease. The most common types of palate defects seen in this series are usually not evident on physical examination and thus require a high index of suspicion and active evaluation through nasopharyngoscopy. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“We demonstrated SN-38 cost a simple method for the device design of a staggered herringbone micromixer (SHM) using
numerical simulation. By correlating the simulated concentrations with channel length, we obtained a series of concentration versus channel length profiles, and used mixing completion length L(m) as the only parameter to evaluate the performance of device structure on mixing. Fluorescence quenching experiments were subsequently conducted to verify the optimized SHM structure for a specific application. Good agreement was found between the optimization and the experimental data. Since L(m) is straightforward, easily defined and calculated parameter for characterization of mixing performance, this method for designing micromixers is simple and effective for practical applications. (C) 2010 American Institute of Physics. [doi:10.1063/1.3427240]“
“Objective: Electrical stimulation by a cochlear implant (CI) induces maturation of the auditory system and reorganization of the auditory cortex in deaf children.
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