The ORs for quintiles of seafood intake
(including fish and shellfish) were 1.00, 1.49, 1.35, 1.34, and 1.56 (p for trend: 0.01). An inverse association approaching significance between soy food consumption and hyperuricemia was observed (ORs: 1.00, 0.90, 0.70, 0.89, and 0.77 for quintiles of intake; p for trend: 0.07). No associations between consumption of purine-rich vegetables or meat and prevalence of hyperuricemia were observed.
Conclusions: Our data suggest a direct association between seafood consumption and hyperuricemia and an inverse association between consumption of soy food and hyperuricemia among middle-aged, Chinese men. (C) 2010 Elsevier B.V. All rights reserved.”
“Purpose: PP2 mw To investigate Blebbistatin inhibitor changes in gonadal white adipose tissue and lipogenesis-related gene expression induced by radiation exposure.
Materials and methods: Groups of
two-month-old C57BL/6 mice were exposed whole-body to (137)Cs gamma-rays at a single dose (5 gray [Gy]) or fractionated doses (1 Gy x 5 times, 0.5 Gy x 10 times, or 0.2 Gy x 25 times). Six months after irradiation, gonadal white adipose tissue was isolated from mice. Two and 25-month-old mice were used as young and old study references. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was used to measure messenger RNA (mRNA) expression of genes related to: (i) Primary lipid metabolism (ATP-citrate lyase [ACL], selleck chemicals malic enzyme1 [ME1] and glucose-6-phosphate dehydrogenase 2 [G6PD2]), (ii) glucose uptake (glucose transporter 4 [GLUT4]), (iii) fatty acid synthesis (sterol regulatory element binding transcription factor 1 [SREBP-1c], fatty acid synthetase [FAS] and acetylcoenzyme A carboxylase beta [ACC]), (iv) triglyceride synthesis (diacylglycerol O-acyltransferase 1 [DGAT1] and diacylglycerol O-acyltransferase 2 [DGAT2]), and (v) adipose-derived
hormones (leptin [LEP]).
Results: The weight of gonadal white adipose tissue in the irradiated groups tended to increase compared to the non-irradiated group though the radiation-induced increase in white adipose tissue was only significant for the 561 Gy group. The mRNA levels of SREBP-1c, ACC, FAS, ACL, GLUT4, ME1 and G6PD2 were relatively lower in gamma-irradiated groups than in non-irradiated groups. The mRNA levels of leptin and DGAT were relatively higher than non-irradiated groups. The changes in expression of these lipogenesis-related genes caused by gamma-irradiation showed a very similar pattern to changes caused by ageing.
Conclusions: A physical agent such as gamma-rays can trigger biological responses resulting in fat accumulation of gonadal white adipose tissue in mice.”
“Monodispersed ferrite nanoparticles of Fe3O4, MnFe2O4, and CoFe2O4 (near to 10 nm), were synthesized by organometallic synthesis, showing the same homogeneous chemical, morphological, and crystalline characteristics.
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