The remaining 22 publications met eligibility criteria and were i

The remaining 22 publications met eligibility criteria and were included in this analysis.[12-33] Alectinib nmr The majority of included studies were observational (n = 19, 86%) and were evaluated using STROBE criteria. Three publications detailed experimental or quasi-experimental designs and were evaluated according to

CONSORT criteria.[28, 32, 33] The reviewers’ initial observed agreement on presence or absence of critical information in three randomized studies was high (observed agreement on all criteria for an individual study = 80–81%; kappa range = 0.56–0.68; all P < 0.001). Reviewers had moderate to high agreement on the critical information presented in 19 observational studies (observed agreement on all criteria for an individual study VX-809 in vivo 65–100%; kappa range = 0.39–1.00; all P ≤ 0.001). Table 1 presents a summary of the critical information that was included in observational studies as evaluated by STROBE. Of the 19 studies evaluated, no single study reported

all of the critical information suggested by the STROBE guidelines. If the non-applicable criteria for each study were discarded, then studies reported an average of 56% of the remaining criteria suggested by STROBE. These publications were most consistent at listing the key elements of study design (such as population, intervention, control, outcomes) early in the paper, described the settings and/or locations, defined basic study outcomes, described follow-up time and included summary measures. Zero manuscripts stated their study design in the title or abstract or included a study flow diagram. Authors generally failed to address loss to follow up, any plans for handling missing data, sensitivity analyses or the generalizability of their study results (included in 8%, 11%, 0% and 11% of applicable studies respectively). The three randomized trials described in Table 2 each included an average learn more of 80% of the information recommended by the CONSORT guidelines when criteria not applicable

to each study were discarded. Criteria that were less frequently met included describing how sample size was derived (0 studies), detailing additional subgroup or adjusted analyses (1 study), rigorous descriptions of study generalizability (0 studies) and providing information about access to the full study protocol and registration of the clinical trial (0 studies). Of note, one of the studies (Levy) was published prior to the time the International Committee of Medical Journal Editors issued their recommendation for all clinical trials to be registered prior to publication.[33, 34] Table 3 summarizes inclusion of additional criteria that were important to studies of HIV pharmacists, as deemed by the reviewers.

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