The statistical analysis showed that labelling density was significantly lower in diabetic than in non-diabetic parotid glands and that diabetes affects protein expression at identical extent in parotid and submandibular glands. The results strengthen selleck compound the hypothesis
that a reduced statherin secretion may be responsible for the higher incidence of oral disorders in diabetic subjects. Oral Diseases (2012) 18, 360-364″
“Protein phosphorylation is a central regulatory mechanism of cell signaling pathways. This highly controlled biochemical process is involved in most cellular functions, and defects in protein kinases and phosphatases have been implicated in many diseases, highlighting the importance of understanding phosphorylation-mediated signaling networks. However, phosphorylation is a transient modification, and phosphorylated proteins are often less abundant. Therefore, the large-scale identification and quantification of phosphoproteins and their phosphorylation sites under different conditions are one of the most interesting
and challenging tasks in the field of proteomics. Both 2D gel electrophoresis and liquid chromatography-tandem mass spectrometry serve as key phosphoproteomic technologies in combination with prefractionation, such as enrichment selleck kinase inhibitor of phosphorylated proteins/peptides. Recently, new possibilities for quantitative phosphoproteomic analysis have been offered by technical advances in sample preparation, enrichment, separation, instrumentation, quantification and informatics. In this article, we present an overview of several strategies RSL3 manufacturer for quantitative phosphoproteomics and discuss how phosphoproteomic analysis can help to elucidate signaling pathways that regulate
various cellular processes.”
“The antioxidant properties and total phenolic of different extracting solvents of thyme, sage, and marjoram were examined using the stable 2,2-diphenyl-1-picrylhydrazyl-hydrate (DPPH center dot) free radical scavenging method and Folin-Ciocalteu method, respectively. Methanol exhibited the highest extraction ability for such phenolic compound, where the total phenols were 8.10, 5.95, and 5.20 (mg gallic acid equivalent/g dry weight) for thyme, sage, and marjoram, respectively and also exhibited the strongest antioxidant capacity. On the basis of the results obtained, thyme, sage, and marjoram have a potential use as natural antioxidants due to their significant antioxidant activity. HPLC analysis of methanolic extract showed the presence of: rosmarenic acid, methyl rosmarenate, caffeic acid, cinnamic acid, chlorogenic acid and quinic acid as phenolic acids, besides some flavonoids such as ferulic acid, apigenin, luteolin and quercetin. The results demonstrated that thyme methanol extract possessed the best antioxidative activity, which were better than those of other plants, alpha-tocopherol and BHA. (c) 2012 Elsevier B.V. All rights reserved.
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