The unresolved problems related to chemotherapy,
other invasive therapeutic procedures and various Nec-1s cell line obstructions offered by biological barriers are circumvented by nanodrug delivery. Recent dramatic developments in nanotechnology have created a lot of nano-devices which could be used against cancer. Infiltration, modulation of the Blood Brain Barrier, camouflaged from immune defense mechanism and the specific targeting of cancer affected cells are a few of the attractive features of nanodevices. We present here a review of newly evolved nanoplatforms in brain tumor therapy in which careful attention has been paid into various form nanoparticles, useful targeting ligands, altered chemotherapy agents and existing tumor therapy methods using nanotechnology.”
“Due to their intrinsic isotropic magnetic properties, LEE011 soft magnetic composite (SMC) materials are applied in electrical machines in which the magnetic energy can be transported in three dimensions (3-D). However, in real applications, complicated magnetic properties such as anisotropy and nonlinearity, are found, in particular, at ahigh frequency
range. This paper studies the 3-D magnetic properties of SMC materials under complicated magnetizations, such as circular, elliptical, and spherical excitations. The magnetic flux density vector B loci, magnetic field strength vector H loci, and core losses at magnetization frequencies ranging from 50-1000 Hz were measured and discussed using an improved 3-D testing system. Experimental results show that rotational core losses are greater than alternating losses at the same magnitude of flux density. In addition,
rotational loss increases sharply around the saturation point, but is not observed in alternating loss. (C) 2011 American Institute of Physics. [doi:10.1063/1.3536336]“
“The obesity pandemic has grown to concerning proportions in recent years, not only in the Western World, but in developing countries as well. The corresponding decrease in male fertility and fecundity may be explained in parallel to obesity, and obesity should be considered as an etiology of male fertility. Studies show that obesity contributes to infertility by reducing semen quality, changing sperm proteomes, contributing MLN4924 price to erectile dysfunction, and inducing other physical problems related to obesity. Mechanisms for explaining the effect of obesity on male infertility include abnormal reproductive hormone levels, an increased release of adipose-derived hormones and adipokines associated with obesity, and other physical problems including sleep apnea and increased scrotal temperatures. Recently, genetic factors and markers for an obesity-related infertility have been discovered and may explain the difference between fertile obese and infertile obese men. Treatments are available for not only infertility related to obesity, but also as a treatment for the other comorbidities arising from obesity.
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