These check details differences highlight the importance of dosage and procedure of using GO, in that very different biological effects
of GO may be generated depending on the experimental conditions. Conclusions In summary, we observed that GO-Ag enhanced the DC-mediated anti-glioma immune response in vitro. Moreover, the immune response induced by GO-Ag appeared to be target-specific. Additionally, GO did not affect the viability or the phenotype of the DCs under our experimental conditions. These results indicated that GO might have potential utility for modulating DC-mediated anti-glioma immune reactions. Acknowledgements X-DY acknowledges the funding support from the Natural Science Foundation of China (NSFC) (81071870) and the Chinese Ministry of Science and Technology (2011CB933504). YF acknowledges the funding support from the NSFC under grant numbers 21173055 and 21161120321. WW Selisistat chemical structure acknowledges the project (RDB2012-08) supported by Peking University People’s Hospital Research and Development Funds. References 1. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, DMXAA mouse Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352:987–996.CrossRef 2. Vredenburgh JJ, Desjardins
A, Herndon JE 2nd, Dowell JM, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Wagner M, Bigner DD, Friedman AH, Friedman HS: Phase II trial of bevacizumab and irinotecan in recurrent
malignant glioma. Clin Canc Res 2007, 13:1253–1259.CrossRef 3. Giese A, Westphal M: Treatment of malignant glioma: a problem beyond the margins of resection. J Canc Res Clin Oncol 2001, 127:217–225.CrossRef 4. Florfenicol Halperin EC, Burger PC, Bullard DE: The fallacy of the localized supratentorial malignant glioma. Int J Radiat Oncol Biol Phys 1988, 15:505–509.CrossRef 5. Stewart LA: Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 2002, 359:1011–1018.CrossRef 6. Brossart P: Dendritic cells in vaccination therapies of malignant diseases. Transfus Apher Sci 2002, 27:183–186.CrossRef 7. Yu JS, Liu G, Ying H, Yong WH, Black KL, Wheeler CJ: Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. Canc Res 2004, 64:4973–4979.CrossRef 8. Yamanaka R, Homma J, Yajima N, Tsuchiya N, Sano M, Kobayashi T, Yoshida S, Abe T, Narita M, Takahashi M, Tanaka R: Clinical evaluation of dendritic cell vaccination for patients with recurrent glioma: results of a clinical phase I/II trial. Clin Canc Res 2005, 11:4160–4167.CrossRef 9. Kikuchi T, Akasaki Y, Abe T, Fukuda T, Saotome H, Ryan JL, Kufe DW, Ohno T: Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12.
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