Total peroxide (TPX) concentrations and total antioxidant response (TAR) were measured in follicular fluid and blood https://www.selleckchem.com/products/CP-673451.html plasma, and an oxidative stress index (OSI) was calculated based on these two parameters. Urinary concentrations of 8-iso-prostaglandin F-2a (F(2)IsoP) were measured. Elevated intrafollicular
oxidative stress was positively correlated with ovarian stimulation outcome: less FSH per retrieved oocyte was used, more oocytes were collected and higher serum oestradiol concentrations were measured in patients with higher follicular OSI. However, high urinary F(2)IsoP related to lower embryo quality and F2IsoP was also elevated in smoking patients. Patients with endometriosis
had lower follicular antioxidant status. Most importantly, higher systemic blood TAR was significantly favourable for achieving clinical pregnancy (P = 0.03). In conclusion, the findings suggest clear associations between oxidative stress, antioxidant status and several aspects of ovarian stimulation and IVF/ICSI outcome, including pregnancy rate. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Treatment of pilonidal sinus disease is controversial. Many claim policy of marsupialisation and healing by secondary intention. This is demanding in terms of nursing care and time lost from work.
To examine outcome of excision and primary closure of chronic pilonidal disease on recurrence rate and patient’s daily activities.
One Selleckchem GSK923295 hundred and fourteen consecutive elective patients who had excision and primary closure of pilonidal sinus disease were reviewed. The demographic
SNS-032 data and the post-operative outcome were studied.
The recurrence of pilonidal sinus was noted in 9% of patients, wound breakdown occasioning delayed healing in 9%, patients able to drive by day 16 on average. The mean time to return to work was 20.5 days; duration of analgesia, 2.4 days; and duration of antibiotic treatment, 4.7 days.
Excision and primary closure of chronic pilonidal sinus has low recurrence rate with early return to activities. Primary closure appears to be a cost-effective option for uncomplicated pilonidal sinus disease.”
“First principles calculations are employed to investigate both type I and II silicon clathrates. The phonon and infrared spectra of both types of clathrate are obtained. We find a localized vibrational mode of Si46 whose frequency is 375.0 cm(-1), where the vibration in the mode localizes in the hexagonal chain. The heat capacity of both clathrates is the same as that of the diamond phase Si (d-Si). When the temperature is lower than 100 K, the Debye temperatures of the clathrates are higher than that of d-Si; however, the Debye temperatures of both clathrates at high temperature (>100 K) are lower than that of the d-Si.
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